Particle-filtering approaches for nonlinear Bayesian decoding of neuronal spike trains

TL;DR

This paper introduces the spike-based Neural Particle Filter (sNPF), an unweighted particle filtering method for nonlinear Bayesian decoding of neuronal spike trains, overcoming the curse of dimensionality faced by traditional weighted filters.

Contribution

The paper develops and analyzes the sNPF, an unweighted particle filter for point-process neural data, demonstrating its scalability and deriving parameter learning rules from maximum likelihood.

Findings

sNPF scales better with increasing dimensions than weighted filters

Theoretical analysis links COD to effective particle number decay

Decoding performance improves with sNPF in simulated tasks

Abstract

The number of neurons that can be simultaneously recorded doubles every seven years. This ever increasing number of recorded neurons opens up the possibility to address new questions and extract higher dimensional stimuli from the recordings. Modeling neural spike trains as point processes, this task of extracting dynamical signals from spike trains is commonly set in the context of nonlinear filtering theory. Particle filter methods relying on importance weights are generic algorithms that solve the filtering task numerically, but exhibit a serious drawback when the problem dimensionality is high: they are known to suffer from the 'curse of dimensionality' (COD), i.e. the number of particles required for a certain performance scales exponentially with the observable dimensions. Here, we first briefly review the theory on filtering with point process observations in continuous time. Based on this theory, we investigate both analytically and numerically the reason for the COD of weighted particle filtering approaches: Similarly to particle filtering with continuous-time observations, the COD with point-process observations is due to the decay of effective number of particles, an effect that is stronger when the number of observable dimensions increases. Given the success of unweighted particle filtering approaches in overcoming the COD for continuous- time observations, we introduce an unweighted particle filter for point-process observations, the spike-based Neural Particle Filter (sNPF), and show that it exhibits a similar favorable scaling as the number of dimensions grows. Further, we derive rules for the parameters of the sNPF from a maximum likelihood approach learning. We finally employ a simple decoding task to illustrate the capabilities of the sNPF and to highlight one possible future application of our inference and learning algorithm.