Review: the development of neural stem cell biology and technology in regenerative medicine

TL;DR

This review discusses the progress in neural stem cell biology and technology, highlighting their potential in regenerative medicine for neurodegenerative diseases and recent advancements in isolation, differentiation, and transplantation techniques.

Contribution

It provides a comprehensive overview of neural stem cell sources, methods, and technological developments, emphasizing future clinical applications and ethical considerations.

Findings

Neural stem cells can potentially replace damaged neurons in humans.

Technological advances are accelerating NSC differentiation and maturation.

Future transplantation of NSCs into human brains is feasible within this century.

Abstract

In the middle of the last century, it has been known that neural stem cells (NSCs) play a key role in regenerative medicine to cure the neurodegenerative disease. This review article covers about the introduction to neural stem cell biology and the isolation, differentiation and transplantation methods/techniques of neural stem cells. The neural stem cells can be transplanted into the human brain in the future to replace the damaged and dead neurons. The highly limited access to embryonic stem cells and ethical issues have escalated the search for other NSC sources. The developing technologies are indicating that it can be achieved before the end of this century. In addition, the differentiation and the maturation of NSCs can artificially accelerate by modern methods.