TL;DR
Fodis is an open-source software tool designed to standardize and automate the analysis of single-molecule force spectroscopy data, enabling classification of unfolding pathways and structural heterogeneity in protein unfolding studies.
Contribution
The paper introduces Fodis, a novel open-source software that automates and standardizes the analysis of SMFS data, including pathway classification and heterogeneity assessment.
Findings
Automates analysis of force-distance curves
Classifies unfolding pathways and heterogeneity
Facilitates data sharing among researchers
Abstract
The folding dynamics of proteins at the single molecule level has been studied with single-molecule force spectroscopy (SMFS) experiments for twenty years, but a common standardized method for the analysis of the collected data and for the sharing among the scientific community members is still not available. We have developed a new open source tool, Fodis, for the analysis of the Force-distance curves obtained in SMFS experiments, providing an almost automatic processing, analysis and classification of the obtained data. Our method provides also a classification of the possible unfolding pathways and structural heterogeneity, present during the unfolding of proteins.
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