Biomolecular System Energetics
Peter J. Gawthrop, Edmund J. Crampin
TL;DR
This paper explores the efficiency of biomolecular energy transduction, specifically glycolysis, using bond graph models to provide new insights into metabolic processes and their evolutionary significance.
Contribution
It introduces new results on metabolic efficiency derived from bond graph models of glycolysis, advancing energy-oriented modeling in biology.
Findings
Bond graph models effectively describe glycolytic energy transduction.
New efficiency metrics for metabolism are proposed.
Results highlight the evolutionary importance of energy transduction mechanisms.
Abstract
Efficient energy transduction is one driver of evolution; and thus understanding biomolecular energy transduction is crucial to understanding living organisms. As an energy-orientated modelling methodology, bond graphs provide a useful approach to describing and modelling the efficiency of living systems. This paper gives some new results on the efficiency of metabolism based on bond graph models of the key metabolic processes: glycolysis.
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Taxonomy
TopicsMitochondrial Function and Pathology · Microbial Metabolic Engineering and Bioproduction · ATP Synthase and ATPases Research