Global generalized solutions to a nonlinear Keller-Segel equation with singular sensitivity
Jianlu Yan, Yuxiang Li

TL;DR
This paper proves the existence of global generalized solutions for a nonlinear Keller-Segel chemotaxis system with singular sensitivity in bounded domains, under specific conditions on the nonlinear diffusion exponent.
Contribution
It establishes the existence of global solutions for a class of nonlinear Keller-Segel equations with singular sensitivity, extending previous results to more general initial data and parameter ranges.
Findings
Global generalized solutions exist for the system when m > 1 + (n-2)/(2n).
Solutions are valid for reasonably regular initial data u_0 ≥ 0, v_0 > 0.
The results apply in smooth bounded domains in R^n for n ≥ 2.
Abstract
We consider the chemotaxis system \begin{eqnarray*} \begin{cases} \begin{array}{lll} \medskip u_t =\Delta u^m - \nabla(\frac{u}{v}\nabla v),&{} x\in\Omega,\ t>0, \medskip v_t =\Delta v -uv,&{}x\in\Omega,\ t>0, \medskip \frac{\partial u}{\partial \nu}=\frac{\partial v}{\partial\nu}=0,&{}x\in\partial\Omega,\ t>0, \medskip u(x,0)=u_0(x),\ v(x,0)=v_0(x), &{}x\in\Omega, \end{array} \end{cases} \end{eqnarray*} in a smooth bounded domain , . In this work it is shown that for all reasonably regular initial data and , the corresponding Neumann initial-boundary value problem possesses a global generalized solution provided that .
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Taxonomy
TopicsMathematical Biology Tumor Growth · Gene Regulatory Network Analysis · Cancer Cells and Metastasis
