Renormalized solutions to a chemotaxis system with consumption of chemoattractant
Hengling Wang, Yuxiang Li

TL;DR
This paper establishes the existence of at least one global renormalized solution for a high-dimensional chemotaxis system with chemoattractant consumption, under specific initial data conditions and Neumann boundary conditions.
Contribution
It proves the existence of global renormalized solutions for a chemotaxis system in dimensions four and higher with particular initial data requirements.
Findings
Existence of global renormalized solutions in dimensions n≥4.
Solutions exist under initial data in specific function spaces.
The model accounts for chemoattractant consumption and boundary conditions.
Abstract
This paper investigates a high-dimensional chemotaxis system with consumption of chemoattractant \begin{eqnarray*} \left\{\begin{array}{l} u_t=\Delta u-\nabla\cdot(u\nabla v), v_t=\Delta v-uv, \end{array}\right. \end{eqnarray*} under homogeneous boundary conditions of Neumann type, in a bounded convex domain with smooth boundary. It is proved that if initial data satisfy and for some , the model possesses at least one global renormalized solution.
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Taxonomy
TopicsMathematical Biology Tumor Growth · Advanced Mathematical Modeling in Engineering · Nonlinear Partial Differential Equations
Renormalized solutions to a chemotaxis system with consumption of chemoattractant
Wang Hengling
Department of Mathematics, Southeast University, Nanjing 210096, P. R. China
and
Li Yuxiang
Department of Mathematics, Southeast University, Nanjing 210096, P. R. China
Abstract.
This paper investigates a high-dimensional chemotaxis system with consumption of chemoattractant
[TABLE]
under homogeneous boundary conditions of Neumann type, in a bounded convex domain with smooth boundary. It is proved that if initial data satisfy and for some , the model possesses at least one global renormalized solution.
Key words and phrases:
Keller-Segel model; Renormalized solutions; Entropy method; Global existence
2000 Mathematics Subject Classification:
35A01, 35K57, 35Q92, 92C17.
Supported in part by NSF of China (No. 11671079, 11601127, 11701290) and NSF of Jiangsu Province (No. BK20170896).
1. Introduction
In this paper, we consider the global existence of renormalized solutions to the chemotaxis system with consumption of chemoattractant
[TABLE]
in a bounded convex domain with smooth boundary, where the scalar functions and denote bacterial density and the oxygen concentration, respectively. and are given functions. denotes the differentiation with respect to the outward normal derivative on . Model (1.5) was initially introduced by Keller and Segel [11] to describe the traveling band behavior of chemotactic bacteria, that is, the biased movement of bacteria to the oxygen concentration gradient. It can be regarded as the ‘fluid-free’ version of the coupled chemotaxis-fluid model which was first presented in [17]. Aerobic bacteria such as Bacillus subtilis often live in thin fluid layers near solid-air-water contact line, in which the biology of chemotaxis, metabolism, and cell-cell signaling is intimately connected to the physics of buoyancy, diffusion, and mixing [17].
In the last few years, model (1.5) has been studied by some authors. It has been shown by Tao [15] that (1.5) admits global classical bounded solutions under the assumption that and be sufficiently small. In [16], Tao and Winkler proved that if , (1.5) possesses a unique global classical solution which is bounded and satisfies and as ; in the case , for arbitrary large initial data, this problem possesses at least one global weak solution which becomes eventually smooth and also satisfies as . Furthermore, Zhang and Li [24] obtained that if either or , the global classical solution of (1.5) converges to exponentially in the large time limit. Similarly, the chemotaxis fluid system has been investigated by some authors, we refer to [7, 13, 20, 14, 21, 23] for the further reading.
The concept of renormalized solutions was introduced by Diperna and Lions [4, 5, 6]. In [8], Fischer established the global existence of renormalized solutions to reaction-diffusion systems with entropy-dissipating reactions. Chen and Jüngel [3] proved the global-in-time existence of renormalized solutions to reaction-cross-diffusion systems for an arbitrary number of variables in bounded domains with no-flux boundary conditions. For the global existence of renormalized solutions of the Landau equation and Boltzmann equation, see for example [1, 2, 18]. Recently, it was shown in [22] that the Keller-Segel system with singular sensitivity and signal absorption admits renormalized radial solutions which are continuous in and smooth in , and which solve the corresponding initial-boundary value problem in an appropriate generalized sense.
To the best of our knowledge, for arbitrarily large initial data, whether any kind of solution to (1.5) in high-dimensional exists globally has been an open problem. The difficulty mainly arises from the cross-diffusive term in the first equation when considering the global existence of weak solutions. The known energy estimates are not sufficient to guarantee the boundedness of in . Therefore, we consider renormalized solutions.
Main results. As usual, we shall assume that the initial data and satisfy
[TABLE]
Our main result reads as follows.
Theorem 1.1**.**
Let be a bounded convex domain with smooth boundary, and suppose that and satisfy (1.8). Then there exists a global renormalized solution of (1.5) in the sense of Definition 5.1 below.
In order to construct renormalized solutions, we use the notation from [8]. Let , be truncation function subject to the following conditions:
(E1) Let .
(E2) Assume that there exists so that holds for all and all .
(E3) Suppose that for every the set supp is bounded.
(E4) Assume that holds for all .
(E5) Suppose that there exists such that holds for every and every .
(E6) Assume that holds for any with .
(E7) Suppose that we have for every .
Such truncations satisfying (E1)-(E7) can indeed be constructed. Let be a smooth nonincreasing function taking values in with for and for . Define
[TABLE]
Then one verifies readily that satisfy conditions (E1)-(E7). Note that we shall also use the same family of truncations in the construction of our renormalized solutions below.
The rest of this paper is organized as follows. In Section 2, we introduce a family of regularized problems and give some preliminary properties. Based on an energy-type inequality, a priori estimates are given in Section 3. Section 4 is devoted to showing the global existence of the regularized problems. Finally, we give the proof of the main result in Section 5.
2. Approximate problems
According to the idea from [16], we consider the approximate problems
[TABLE]
where .
The approximate function in (2.5) can be chosen as
[TABLE]
Note that our choice of ensures that
[TABLE]
[TABLE]
and that
[TABLE]
All the above approximate problems admit local-in-time smooth solutions:
Lemma 2.1**.**
Suppose that and satisfy (1.8), then for any , there exist and a classical solution of (2.5) in . Moreover, if , then
[TABLE]
The proof of this lemma is based on well-established methods involving the Banach fixed point theorem, the standard regularity theories of parabolic equations (see [20] for instance).
The following estimates of and are basic but important in the proof of our result.
Lemma 2.2**.**
For each , we have
[TABLE]
and
[TABLE]
Proof.
Integrating the first equation in (2.5), we obtain (2.10). And an application of the maximum principle to the second equation in (2.5) gives (2.11). ∎
3. A priori estimates
This section is devoted to establishing an energy-type inequality which will play a key role in the derivation of further estimates.
Lemma 3.1**.**
For each , the solution of (2.5) satisfies
[TABLE]
for all .
Proof.
The proof is based on the first two equations in (2.5) and integration by parts, we refer readers to [20, Lemmas 3.1-3.4] for details. ∎
We next collect some consequences of the above energy inequality which are convenient for our purpose.
Corollary 3.2**.**
There exists such that for all and , the solution of (2.5) satisfies
[TABLE]
[TABLE]
[TABLE]
[TABLE]
Proof.
Integrating (3.1), according to the inequality for and (2.11), we obtain the desired results. ∎
Lemma 3.3**.**
([20, Lemma 4.1])* Suppose that and that is a bounded domain with smooth boundary. Let and be such that*
[TABLE]
and
[TABLE]
Then, for all and each , there exists such that if is nonnegative with
[TABLE]
then the estimate
[TABLE]
holds.
In view of (2.10), the above lemma immediately implies the following.
Corollary 3.4**.**
Suppose that . Then for all , there exists such that for any , the solution of (2.5) satisfies
[TABLE]
Proof.
It is a consequence of Corollary 3.2 and of Lemma 3.3 applied to and . ∎
4. Global solvability for the approximate problems
Now we are in position to show that the solution of the approximate problem (2.5) is actually global in time. The idea of the proof is based on the argument in [20]. Throughout this section, all constants below possibly depend on .
Lemma 4.1**.**
For each , we have ; that is, the solutions of (2.5) are global in time.
Proof.
Assume that for some . Now pick ensures that . Moreover,
[TABLE]
This entails that
[TABLE]
because of (2.10) and (2.11). As a consequence of (4.1), the variation-of-constants formula and well-known smoothing estimates for the Neumann heat semigroup [19, Lemma 1.3] yield the estimate
[TABLE]
with certain positive constants and .
We next use (4.2) to estimate . Now taking any \beta\in\big{(}\frac{n}{2q},\frac{1}{2}\big{)} and letting denote the operator in with homogeneous Neumann data, we have (see for example [10]) and hence we find positive constants and such that
[TABLE]
Combined with (4.2), this contradicts (2.9) and thereby proves that . ∎
5. Existence of renormalized solutions
Having established the existence of solutions for our approximate problem, we turn to the proof of the existence of renormalized solutions to the original equations (1.5). Before going into detail, let us first give the definition of renormalized solutions.
Definition 5.1**.**
Suppose that , that is a bounded domain and that and are nonnegative. Then a pair of functions
[TABLE]
satisfying and a.e. in , will be called a global renormalized solution of (1.5) if for all with we have
[TABLE]
for all , and if moreover the identity
[TABLE]
is valid for any .
In the first step, we show that a subsequence of the solutions to the approximate problems (2.5) converges to some limit as .
Lemma 5.1**.**
Consider a sequence of solutions to the approximate problems, with converging to zero. Then there exists a subsequence (not relabeled) which converges almost everywhere on to some limit with . Moreover, the convergence weakly in holds for all .
Proof.
Let be as in (1.9). Noting that
[TABLE]
and that supp is a compact subset of , by uniform (with respect to ) boundedness of in for every [this is a consequence of Corollary 3.2 and (2.10)] we see that is uniformly bounded with respect to in for every fixed and every fixed .
Let be a smooth function. Testing the first equation of (2.5) by and integrating by parts, we have
[TABLE]
Using the fact that supp is a compact subset of and the fact that is uniformly (with respect to ) bounded in for every , we see that is bounded uniformly in for every and every fixed .
Since , we may combine this with the boundedness of in to obtain from the Aubin-Lions Lemma (see for example [12]) that the sequence is relatively compact in for every fixed and fixed . By a diagonal sequence argument (we do not relabel the subsequence), we may assume that for every the sequence converges almost everywhere to some measurable limit . From the uniform boundedness of in which holds for every fixed [this is also a consequence of Corollary 3.2] we deduce using (E6) that is also bounded uniformly in for every fixed ; moreover, the boundedness is also uniform with respect to . Thus, by Fatou’s Lemma we know that is almost everywhere finite and is bounded uniformly (with respect to ) in .
We now prove that the pointwise limit exists almost everywhere and define a measurable function with . If for some and some we have , then holds for all : by our choice of we know that implies . If we have , then for small enough it holds that and therefore we get for . Since is bounded uniformly in , the measure of the set of points for which holds tends to zero as ; thus, the limit exists for almost every and defines a measurable function . The estimate is a consequence of Fatou’s Lemma.
The function is now the natural candidate for being a renormalized solution of (1.5).
First we notice that (after possibly passing to another subsequence) converges almost everywhere to . By uniform boundedness of in , the measure of the set of points with tends to zero as , uniformly in ; thus the measure of the set of points for which holds tends to zero as , uniformly in . We have for any
[TABLE]
where by the previous considerations the first term on the right-hand side converges to zero as , uniformly in . The last term tends to zero as by the definition of ; it is independent of . The penultimate term converges to zero as for fixed . To sum up, we have shown that converges to in measure, which implies convergence almost everywhere for a subsequence.
As is bounded uniformly in for every , we deduce that converges to strongly in for every and . This, in particular, implies convergence of to in the sense of distribution, and we obtain that with
[TABLE]
[the latter being finite due to Corollary 3.2]. In particular, converges to weakly in for every . ∎
In the second step, as a preparation for the proof of Theorem 1.1, we show that a subsequence of the solutions to the approximate problems (2.5) converges to some limit as .
Lemma 5.2**.**
Consider a sequence of solutions to the approximate problems, with converging to zero. Then there exists a subsequence (not relabeled)which converges almost everywhere on to some limit . Moreover, satisfies (5.2).
Proof.
Firstly, we show that is strongly precompact in . Then since , in view of (2.11) and Corollary 3.4 we can pick positive constant such that
[TABLE]
for all . This shows that is bounded in , so that standard results on Sobolev regularity for the heat equation [9] assert boundedness of both in and of in . Again by the Aubin-Lions lemma, this shows that is relatively compact in . It is possible to pick a sequence of numbers such that as , the solutions of (2.5) satisfy
[TABLE]
[TABLE]
for some limit function . To see that satisfies (5.2), we fix . Multiplying the second equation in (2.5) by , on integrating by parts we obtain
[TABLE]
Combined with the boundedness of in , we derive that (5.2) by letting and thereby completes the proof. ∎
In the third step of our proof of the existence of renormalized solutions, we show that the ”truncations” of the limit , which has been constructed in the first step, satisfy a certain PDE.
Lemma 5.3**.**
Let be the functions constructed in the previous lemma. Let be the functions defined in (1.9). Let . Then satisfies
[TABLE]
where denotes a sequence of signed Radon measures satisfying
[TABLE]
for all .
Proof.
Let and . For fixed we pass to the limit in (5). Convergence of the left-hand side and of the terms is immediate by the convergence properties proven in previous lemma and by the fact that supp is compact.
Two terms whose convergence cannot be ensured are term . In order to deal with them, we intend to show that they vanish in the limit . Consider the signed measures
[TABLE]
Note that we have
[TABLE]
which follows from the definition of using (E2) and Corollary 3.2 as well as Young’s inequality. The uniform boundedness of in for any implies that after passing to a subsequence we may assume that weak- converges on to some limit as tends to [math].
It remains to prove (5.5). We now consider the measures
[TABLE]
on . Using (E2) and Corollary 3.2 we deduce from (5) that
[TABLE]
By (E3), for fixed only finitely many terms in the series do not vanish. We may therefore pass to the limit . Using the fact that the measure of open sets is lower semicontinuous with respect to weak- convergence of measures, we obtain, after passing to a subsequence (the passage to a subsequence in particular ensuring that the limits in the last line of the next formula exist),
[TABLE]
However, we have
[TABLE]
As the latter quantities are bounded uniformly with respect to , we obtain, using Fatou’s lemma (for the counting measure on ; recall that the limits in the next formula actually exist since we have passed to an appropriate subsequence),
[TABLE]
By dominated convergence applied to the counting measure on (which is possible by (E2) and (E7) as well as the previous estimate), we deduce from (5)
[TABLE]
This finishes the proof of the lemma. ∎
We can now prove our main result.
Proof of Theorem 1.1. In order to show that is a renormalized solution, we apply [8, Lemma 4] to the map in order to approximately identify the weak time derivative of ; then we pass to the limit to deduce the equation for .
More precisely, choose some as arbitrary but fixed; we then prove that is a renormalized solution on . Let be a smooth function with compactly supported derivatives. Recall that satisfies (5.3), we see that in [8, Lemma 4] we need to choose
[TABLE]
Obviously, they satisfy the assumptions of [8, Lemma 4]. Thus, we infer that for any the function must satisfy the estimate
[TABLE]
To obtain the desired equation for , we now pass to the limit . To do so, we use (1.9) as well as (5.5); note that due to (5.5), the left-hand side must be zero in the limit, that is, we obtain an exact equation in the limit. Convergence of the terms in the first line is immediate, as is convergence of the terms in the second and the third line [observe that converges pointwise almost everywhere to and that the is bounded by a constant by (E5)].
It remains to deal with the fourth and the fifth line. To show convergence of the two terms, besides the fact we need the following assertion: there exists a constant such that for all the estimate implies and . Given this assertion, convergence of the remaining terms in the previous formula as is also immediate since one factor in the integrals will be zero as soon as becomes too large.
To show this assertion, choose so large that supp . Let . Then implies and therefore as well as . Combining with Lemma 5.2, we finish the proof of Theorem 1.1.
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