Testing One Hypothesis Multiple Times: The Multidimensional Case
Sara Algeri, David A. van Dyk

TL;DR
This paper extends the TOHM hypothesis testing method to multidimensional cases, providing a computationally efficient algorithm for inference involving complex random fields and high significance levels.
Contribution
It introduces a novel algorithm for computing Euler Characteristics in multiple dimensions, enabling efficient hypothesis testing in complex, high-dimensional settings.
Findings
Efficient algorithm for Euler Characteristic computation in multiple dimensions.
Enables hypothesis testing with high significance levels in complex models.
Provides a generalizable tool for non-standard regularity conditions.
Abstract
The identification of new rare signals in data, the detection of a sudden change in a trend, and the selection of competing models, are among the most challenging problems in statistical practice. These challenges can be tackled using a test of hypothesis where a nuisance parameter is present only under the alternative, and a computationally efficient solution can be obtained by the "Testing One Hypothesis Multiple times" (TOHM) method. In the one-dimensional setting, a fine discretization of the space of the non-identifiable parameter is specified, and a global p-value is obtained by approximating the distribution of the supremum of the resulting stochastic process. In this paper, we propose a computationally efficient inferential tool to perform TOHM in the multidimensional setting. Here, the approximations of interest typically involve the expected Euler Characteristics (EC) of the…
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