K-shell decomposition reveals hierarchical cortical organization of the human brain

TL;DR

This study uses k-shell decomposition to analyze the hierarchical organization of the human brain's cortical network, revealing a structured, efficient, and functionally diverse connectivity pattern that may underpin consciousness.

Contribution

It applies k-shell decomposition to human cortical networks derived from MRI/DSI data, uncovering hierarchical layers and their potential roles in information flow and consciousness.

Findings

The cortex forms a connected giant component with no isolated nodes.

Hierarchical shells correspond to different functional roles.

The nucleus correlates with consciousness-related regions.

Abstract

In recent years numerous attempts to understand the human brain were undertaken from a network point of view. A network framework takes into account the relationships between the different parts of the system and enables to examine how global and complex functions might emerge from network topology. Previous work revealed that the human brain features 'small world' characteristics and that cortical hubs tend to interconnect among themselves. However, in order to fully understand the topological structure of hubs one needs to go beyond the properties of a specific hub and examine the various structural layers of the network. To address this topic further, we applied an analysis known in statistical physics and network theory as k-shell decomposition analysis. The analysis was applied on a human cortical network, derived from MRI\DSI data of six participants. Such analysis enables us to portray a detailed account of cortical connectivity focusing on different neighborhoods of interconnected layers across the cortex. Our findings reveal that the human cortex is highly connected and efficient, and unlike the internet network contains no isolated nodes. The cortical network is comprised of a nucleus alongside shells of increasing connectivity that formed one connected giant component. All these components were further categorized into three hierarchies in accordance with their connectivity profile, with each hierarchy reflecting different functional roles. Such a model may explain an efficient flow of information from the lowest hierarchy to the highest one, with each step enabling increased data integration. At the top, the highest hierarchy (the nucleus) serves as a global interconnected collective and demonstrates high correlation with consciousness related regions, suggesting that the nucleus might serve as a platform for consciousness to emerge.