Achieving Analytical and Cellular Control in Confined Spaces and Continuous Flow

TL;DR

This paper presents a microfluidic system for drug metabolism studies using tissue slices and introduces a novel particle separation method based on controlled bi-directional flow in microchannels.

Contribution

It introduces a microfluidic incubation system for tissue slices and a new particle separation technique utilizing opposing pressure-driven and electrokinetic flows.

Findings

Effective microfluidic incubation for drug metabolism demonstrated.

Novel particle separation method achieved controlled bi-directional flow.

Potential applications in biomedical research and diagnostics.

Abstract

Sabeth Verpoorte is professor at the University of Groningen. In this contribution she describes the development of a microfluidic incubation system for drug metabolism studies using a "top-down" precision-cut tissue slice model. She also outlines a fundamental particle separation concept, which relies on the generation of controlled bi-directional flow in microchannels having variable cross-sectional dimensions, by opposing pressure-driven and electrokinetic flows.