Electrochemical conversions in a microfluidic chip for xenobiotic metabolism and proteomics

TL;DR

This paper discusses the use of microfluidic devices to simulate xenobiotic metabolism and to electrochemically cleave proteins for enhanced proteomic analysis, advancing miniaturized biochemical assays.

Contribution

It introduces microfluidic techniques for in vitro xenobiotic metabolism simulation and protein cleavage, enabling integrated analysis workflows.

Findings

Microfluidic devices can mimic xenobiotic metabolism.

Electrochemical protein cleavage facilitates mass spectrometry.

Potential for improved miniaturized biochemical analysis.

Abstract

Albert van den Berg is a full professor on Miniaturized Systems for (Bio)Chemical Analysis at at the University of Twente. In this contribution he describes how microfluidic techniques can be used to mimic xenobiotic metabolism in vitro. Similar devices can also be used to electrochemically cleave proteins for mass spectrometric detection and database searching.