Spatial dynamics of flower organ formation

TL;DR

This paper presents a systematic framework for constructing Waddington's epigenetic landscape of gene regulatory networks involved in flower organ formation in Arabidopsis thaliana, accurately modeling spatial development and mutants.

Contribution

It introduces a generalizable method to model cellular determination and spatial dynamics in plant development based on experimental data.

Findings

Accurately models spatial configuration of Arabidopsis flower development.

Successfully reproduces wild type and mutant flower structures.

Provides a versatile approach applicable to other organisms.

Abstract

Understanding the emergence of biological structures and their changes is a complex problem. On a biochemical level, it is based on gene regulatory networks (GRN) consisting on interactions between the genes responsible for cell differentiation and coupled in a greater scale with external factors. In this work we provide a systematic methodological framework to construct Waddington's epigenetic landscape of the GRN involved in cellular determination during the early stages of development of angiosperms. As a specific example we consider the flower of the plant \textit{Arabidopsis thaliana}. Our model, which is based on experimental data, recovers accurately the spatial configuration of the flower during cell fate determination, not only for the wild type, but for its homeotic mutants as well. The method developed in this project is general enough to be used in the study of the relationship between genotype-phenotype in other living organisms.