Volume entropy and information flow in a brain graph

TL;DR

This paper introduces volume entropy, a new graph invariant for brain networks, which quantifies information flow and distinguishes graph topology better than existing measures, with applications to aging-related brain changes.

Contribution

It proposes volume entropy as a novel measure for brain graphs, modeling information flow via a generalized Markov system and estimating it through stationary equations.

Findings

Volume entropy effectively differentiates graph topology and geometry.

Volume entropy correlates with healthy aging from 20s to 60s.

Stationary distribution reveals information flow patterns in brain graphs.

Abstract

Entropy is a classical measure to quantify the amount of information or complexity of a system. Various entropy-based measures such as functional and spectral entropies have been proposed in brain network analysis. However, they are less widely used than traditional graph theoretic measures such as global and local efficiencies because either they are not well-defined on a graph or difficult to interpret its biological meaning. In this paper, we propose a new entropy-based graph invariant, called volume entropy. It measures the exponential growth rate of the number of paths in a graph, which is a relevant measure if information flows through the graph forever. We model the information propagation on a graph by the generalized Markov system associated to the weighted edge-transition matrix. We estimate the volume entropy using the stationary equation of the generalized Markov system. A prominent advantage of using the stationary equation is that it assigns certain distribution of weights on the edges of the brain graph, which we call the stationary distribution. The stationary distribution shows the information capacity of edges and the direction of information flow on a brain graph. The simulation results show that the volume entropy distinguishes the underlying graph topology and geometry better than the existing graph measures. In brain imaging data application, the volume entropy of brain graphs was significantly related to healthy normal aging from 20s to 60s. In addition, the stationary distribution of information propagation gives a new insight into the information flow of functional brain graph.