Study of a Prototype VP-PET Imaging System Based on highly Pixelated CdZnTe Detectors

TL;DR

This paper presents a prototype VP-PET imaging system using highly pixelated CdZnTe detectors, demonstrating high resolution and sensitivity through Monte Carlo simulations for small animal imaging.

Contribution

The study introduces a novel VP-PET system with pixelated CdZnTe detectors and validates its imaging capabilities via detailed GATE simulations.

Findings

Achieved 0.7 mm FWHM spatial resolution.

System sensitivity of 0.46 cps/kBq at CFOV.

Clear separation of 0.5 mm diameter point sources.

Abstract

We are investigating a prototype virtual pinhole positron emission tomography (VP-PET) system for small animal imaging applications. The PET detector modules were made up of 1.3 mm lutetium-yttrium oxyorthosilicate (LYSO) arrays, and the insert detectors consists of 0.6 mm pixelated Cadmium Zinc Telluride (CdZnTe). To validate the imaging experiment, we conducted a Monte Carlo simulation for the VP-PET system in Geant4 Application for Emission Tomography (GATE). For a point source of Na-22 with 0.5 mm diameter, the filtered back-projection (FBP) algorithm reconstructed PET image shows a resolution of 0.7 mm full-width-at-half-maximum (FWHM). The system sensitivity is 0.46 cps/kBq at the center of field view (CFOV) of the PET system with a source activity of 0.925 MBq and an energy resolution of 350-650 keV. A rod source phantom and a Derenzo phantom with F-18 were also simulated to investigate the PET imaging capability. GATE simulation indicated that two point sources with 0.5 mm diameter 2 mm apart could be clearly separated using 0.6 mm pixelated CdZnTe detectors as insert devices in a VP-PET system.