Copper-catalyzed efficient synthesis of 5-arylindazolo[3,2-b]quinazolin-7(5H)-ones from 2-nitrobenzaldehydes

TL;DR

This paper presents a new copper-catalyzed method for synthesizing complex quinazolinone derivatives efficiently, using readily prepared intermediates and 2-nitrobenzaldehydes, achieving good yields.

Contribution

It introduces a practical copper-catalyzed synthesis route for 5-arylindazoloquinazolinones from 2-nitrobenzaldehydes, with straightforward preparation of key intermediates.

Findings

High yields of target compounds achieved.

Method is practical and efficient.

Uses readily available starting materials.

Abstract

A novel and practical copper-catalyzed approach is developed for the preparation of 5-arylindazolo[3,2-b]quinazolin-7(5H)-ones. The 2-amino-N'-arylbenzohydrazide, which easily prepared by reaction of isatoic anhydride with arylhydrazine, through a condensation/intramolecular cyclization reacted by 2-nitrobenzaldehydes in the present of CuI to afford corresponding 5-arylindazolo[3,2-b]quinazolin-7(5H)-ones in good yields.