Modification of the zirconia ceramics by different calcium phosphate coatings:comparative study

TL;DR

This study compares various calcium phosphate coatings on zirconia ceramics, analyzing their physical properties and cell response, highlighting differences in biocompatibility and cell adhesion.

Contribution

It provides a comparative analysis of calcium phosphate coatings formed by RF-magnetron sputtering on zirconia, focusing on their physical properties and biological responses.

Findings

Calcium phosphate dibasic dihydrate and tribasic coatings showed lower cell viability.

Tribasic calcium phosphate coating enhanced cell adhesion.

Coatings exhibited distinct physical and chemical properties.

Abstract

The aim of this study was to characterize different calcium phosphate coatings and evaluate in vitro cell response of these materials to ceramics implants. The physical and chemical properties of calcium phosphate coatings formed by RF-magnetron sputtering of calcium phosphate tribasic, hydroxyapatite, calcium phosphate monobasic, calcium phosphate dibasic dihydrate and calcium pyrophosphate powders were characterized. Cell adhesion and cell viability were examined on calcium phosphate coatings using mesenchymal stem cells. The results of cytotoxicity measurements of the calcium phosphate coatings revealed that only the coating obtained by RF-magnetron sputtering of the calcium phosphate dibasic dihydrate and calcium phosphate tribasic powders possessed lower cell viability than the zirconia substrate. The coating formed by sputtering of the calcium phosphate tribasic powder demonstrated more cells adhered onto its surface compared with other calcium phosphate coatings.