Altered structural connectivity of the left visual thalamus in developmental dyslexia

TL;DR

This study reveals specific structural connectivity deficits between the left visual thalamus and V5/MT in individuals with developmental dyslexia, highlighting the role of subcortical pathways in the disorder.

Contribution

It provides the first in-vivo evidence of altered cortico-thalamic connections in developmental dyslexia, challenging existing models focused solely on cortical abnormalities.

Findings

Reduced left LGN to V5/MT connectivity in dyslexia

Connectivity strength correlates with rapid naming abilities

No significant difference in LGN to V1 connectivity

Abstract

Developmental dyslexia is characterized by persistent reading and spelling deficits. Partly due to technical challenges with investigating subcortical sensory structures, current research on dyslexia in humans by-and-large focuses on the cerebral cortex. These studies found that dyslexia is typically associated with functional and structural alterations of a distributed left-hemispheric cerebral cortex network. However, findings from animal models and post-mortem studies in humans suggest that developmental dyslexia might also be associated with structural alterations in subcortical sensory pathways. Whether these alterations also exist in developmental dyslexia in-vivo and how they relate to dyslexia symptoms is currently unknown. Here we used ultra-high resolution structural magnetic resonance imaging (MRI), diffusion MRI and probabilistic tractography to investigate the structural connections of the visual sensory pathway in dyslexia in-vivo. We discovered that individuals with developmental dyslexia have reduced structural connections in the direct pathway between the left visual thalamus (LGN) and left middle temporal area V5/MT, but not between the left LGN and left primary visual cortex (V1). In addition, left V5/MT-LGN connectivity strength correlated with rapid naming abilities - a key deficit in dyslexia [14]. These findings provide the first evidence of specific structural alterations in the connections between the sensory thalamus and cortex in developmental dyslexia. The results challenge current standard models and provide novel evidence for the importance of cortico-thalamic interactions in explaining dyslexia.