Human Tissues Investigation Using PALS Technique
B. Jasi\'nska, B. Zgardzi\'nska, G. Cho{\l}ubek, M. Gorgol, K. Wiktor,, K. Wysogld, P. Bia{\l}as, C. Curceanu, E. Czerwi\'nski, K. Dulski, A. Gajos,, B. G{\l}owacz, B. Hiesmayr, B. Jod{\l}owska-J\k{e}drych, D. Kami\'nska, G., Korcyl, P. Kowalski, T. Kozik, N. Krawczyk
TL;DR
This study uses PALS to differentiate between healthy and tumorous uterine tissues, revealing significant differences in positron annihilation parameters that could aid in tissue characterization.
Contribution
First application of PALS to compare normal and tumorous uterine tissues, including the novel measurement of the 3γ fraction to assess tissue porosity changes.
Findings
Larger free annihilation and ortho-positronium lifetimes in tumorous tissues.
Smaller annihilation intensities in tumorous tissues.
Introduction of 3γ fraction measurement for tissue porosity analysis.
Abstract
Samples of uterine leiomyomatis and normal tissues taken from patients after surgery were investigated using the Positron Annihilation Lifetime Spectroscopy (PALS). Significant differences in all PALS parameters between normal and diseased tissues were observed. For all studied patients, it was found that the values of the free annihilation and ortho-positronium lifetime are larger for the tumorous tissues than for the healthy ones. For most of the patients, the intensity of the free annihilation and ortho-positronium annihilation was smaller for the tumorous than for the healthy tissues. For the first time, in this kind of studies, the fraction of positron annihilation was determined to describe changes in the tissue porosity during morphologic alteration.
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