A tank-circuit for ultrafast single particle detection in micropores

TL;DR

This paper introduces an ultrafast radio-frequency detection method using a half-bowtie coplanar waveguide for single nanoparticle detection in micropores, significantly surpassing traditional resistive pulse techniques in speed and throughput.

Contribution

The paper presents a novel RF-based detection technique that achieves over 30MHz bandwidth and two orders of magnitude higher throughput than conventional methods.

Findings

Detection bandwidth exceeds 30MHz.

Throughput is enhanced by two orders of magnitude.

Potential for GHz frequency operation.

Abstract

We present an ultrafast single sub-micron particle detection method based on a half-bowtie coplanar waveguide. The method is capable of resolving the translocation of these particles at a bandwidth greater than 30MHz. We compare experimentally the simultaneous use of our radio- frequency technique with conventional DC based resistive pulse recordings and find that our method has a throughput that is enhanced by two orders of magnitude. The technique incorporates a microfluidic circuit and has potential to be employed for screening nano particles and biopolymers such as DNA at frequencies in excess of 1 GHz.