Early pathogen replacement in a model of Influenza and Respiratory Syncytial Virus with partial vaccination. A computational study

TL;DR

This study uses spectral decomposition of a two-pathogen epidemic model to explore how partial vaccination and pathogen interactions influence early pathogen replacement during seasonal influenza and RSV epidemics.

Contribution

It introduces a computational approach analyzing pathogen replacement dynamics considering vaccination and inter-pathogen interactions.

Findings

Partial vaccination impacts pathogen dominance shifts.

Pathogen interactions influence replacement timing.

Spectral analysis reveals stability properties of epidemic states.

Abstract

In this paper, we carry out a computational study using the spectral decomposition of the fluctuations of a two-pathogen epidemic model around its deterministic attractor, i.e., steady state or limit cycle, to examine the role of partial vaccination and between-host pathogen interaction on early pathogen replacement during seasonal epidemics of influenza and respiratory syncytial virus.