Introduction and reconciliation of the ROS and aging paradoxes

TL;DR

This paper proposes a unified view of aging, suggesting it is affected by a balance of pro- and anti-aging factors, with ROS linked more to metabolism than aging itself.

Contribution

It introduces a synthesis reconciling the roles of ROS and protective responses in aging, challenging traditional views.

Findings

Aging is influenced by both pro- and anti-aging factors.

Anti-aging effects may be side effects of retrograde responses.

ROS correlates more with metabolism than with aging.

Abstract

This paper suggests that aging is influenced synthetically by pro-aging factors such as ROS and anti-aging factors such as protective responses. The anti-aging effect may be side effects of retrograde responses motivated against adverse circumstances. ROS may be more closely correlated with metabolism rather than aging.