Emergence of a Balanced Core through Dynamical Competition in Heterogeneous Neuronal Networks

TL;DR

This study reveals that in inhomogeneous neuronal networks, a small active core maintains a balanced state, which is largely independent of the overall network topology and may underpin sparse coding in the brain.

Contribution

It demonstrates that a balanced state exists within an active core in inhomogeneous networks, extending the understanding beyond homogeneous models and suggesting universality across different topologies.

Findings

Active core exhibits high firing rates and balanced state.

Balanced state in the active core is independent of single-neuron models.

Active core connectivity resembles Erdős-Rényi networks.

Abstract

The balance between excitation and inhibition is crucial for neuronal computation. It is observed that the balanced state of neuronal networks exists in many experiments, yet its underlying mechanism remains to be fully clarified. Theoretical studies of the balanced state mainly focus on the analysis of the homogeneous Erd$\ddot{\text{o}}$s-R\'enyi network. However, neuronal networks have been found to be inhomogeneous in many cortical areas. In particular, the connectivity of neuronal networks can be of the type of scale-free, small-world, or even with specific motifs. In this work, we examine the questions of whether the balanced state is universal with respect to network topology and what characteristics the balanced state possesses in inhomogeneous networks such as scale-free and small-world networks. We discover that, for a sparsely but strongly connected inhomogeneous network, despite that the whole network receives external inputs, there is a small active subnetwork (active core) inherently embedded within it. The neurons in this active core have relatively high firing rates while the neurons in the rest of the network are quiescent. Surprisingly, the active core possesses a balanced state and this state is independent of the model of single-neuron dynamics. The dynamics of the active core can be well predicted using the Fokker-Planck equation with the mean-field assumption. Our results suggest that, in the presence of inhomogeneous network connectivity, the balanced state may be ubiquitous in the brain, and the network connectivity in the active core is essentially close to the Erd$\ddot{\text{o}}$s-R\'enyi structure. The existence of the small active core embedded in a large network may provide a potential dynamical scenario underlying sparse coding in neuronal networks.