Near-infrared photothermal response of plasmonic gold-coated nanoparticles in tissues

TL;DR

This paper presents a combined experimental and numerical study of the temperature increase caused by gold-coated nanoparticles in tissues under near-infrared laser irradiation, incorporating medium perfusion effects for improved accuracy.

Contribution

It introduces a bioheat transfer model that accounts for medium perfusion effects, enhancing the analysis of nanoparticle-induced heating in tissues.

Findings

Good agreement between experiments and numerical calculations

Medium perfusion significantly affects temperature rise

Method can estimate nanoparticle distribution and predict temperature profiles

Abstract

We propose a new approach to understand the time-dependent temperature increasing process of gold-silica core-shell nanoparticles injected into chicken tissues under near-infrared laser irradiation. Gold nanoshells strongly absorb near-infrared radiations and efficiently transform absorbed energy into heat. Temperature rise given by experiments and numerical calculations based on bioheat transfer are in good agreement. Our work improves the analysis of a recent study [Richardson et al., Nano Lett. 9, 1139 (2009)] by including effects of the medium perfusion on temperature increase. The theoretical analysis can also be used to estimate the distribution of nanoparticles in experimental samples and provide a relative accuracy prediction for the temperature profile of new systems. This methodology would provide a novel and reliable tool for speeding up photothermal investigations and designing state-of-the-art photothermal devices.