Fabrication and properties of L-arginine-doped PCL electrospun composite scaffolds

TL;DR

This study explores the fabrication of electrospun PCL scaffolds doped with L-arginine, examining how arginine content affects their structure, mechanical, surface, and biological properties, with potential implications for tissue engineering.

Contribution

It introduces a method to produce L-arginine-doped PCL scaffolds via electrospinning and analyzes how arginine concentration influences their properties, highlighting optimal conditions for cell adhesion.

Findings

Increased arginine reduces fiber diameter and enhances scaffold strength.

Porosity and water contact angle are unaffected by arginine content.

Optimal cell adhesion observed at 0.5-1% arginine concentration.

Abstract

The article describes fabrication and properties of composite fibrous scaffolds obtained by electrospinning of the solution of poly({\epsilon}-caprolactone) and arginine in common solvent. The influence of arginine content on structure, mechanical, surface and biological properties of the scaffolds was investigated. It was found that with an increase of arginine concentration diameter of the scaffold fibers was reduced, which was accompanied by an increase of scaffold strength and Young modulus. It was demonstrated that porosity and water contact angle of the scaffold are independent from arginine content. The best cell adhesion and viability was shown on scaffolds with arginine concentration from 0.5 to 1 % wt.