Stability of DNA molecule in conical shaped cellular environment

TL;DR

This study investigates how the conical cellular environment influences the thermal stability of double-stranded DNA, highlighting the significant role of confinement geometry on molecular stability.

Contribution

The paper introduces a model to analyze the impact of conical confinement on DNA stability, emphasizing the importance of geometry in cellular environments.

Findings

Confinement affects DNA melting profiles.

Conical geometry influences DNA stability.

Molecular stability depends on spatial constraints.

Abstract

DNA inside the cellular environment works under a confined space. An intense research of the transcription and replication of DNA in the confined state is structurally significant to command the self assembly of DNA in a chamber or channel. In this work, we consider double stranded DNA (dsDNA) molecules of different length and sequence and study the thermal stability of the molecule in a confined space of conical geometry. Using the Peyrard-Bishop-Dauxois (PBD) model, we evaluate the melting profile of dsDNA that is confined on one side of the conical wall that mimics cellular boundary. Our results show that not only the confinement, but also the geometry of the confined space plays a prominent role in the stability of the molecule.