Fractional cable equation for general geometry, a model of axons with swellings and anomalous diffusion

TL;DR

This paper introduces a fractional cable equation model for axons with complex geometries and swellings, capturing how anomalous diffusion affects voltage propagation relevant to neurodegenerative diseases.

Contribution

It develops a generalized fractional cable equation incorporating geometry and anomalous diffusion, providing insights into voltage behavior in diseased axons.

Findings

Voltage decreases with increased fractional effect.

Swellings and fractional effects both reduce voltage.

Combined swellings and fractional effects cause dramatic voltage decrease.

Abstract

Different experimental studies have reported anomalous diffusion in brain tissues and notably this anomalous diffusion is expressed through fractional derivatives. Axons are important to understand neurodegenerative diseases such as multiple sclerosis, Alzheimer's disease and Parkinson's disease. Indeed, abnormal accumulation of proteins and organelles in axons is a hallmark feature of these diseases. The diffusion in the axons can become to anomalous as a result from this abnormality. In this case the voltage propagation in axons is affected. Another hallmark feature of different neurodegenerative diseases is given by discrete swellings along the axon. In order to model the voltage propagation in axons with anomalous diffusion and swellings, in this paper we propose a fractional cable equation for general geometry. This generalized equation depends on fractional parameters and geometric quantities such as the curvature and torsion of the cable. For a cable with a constant radius we show that the voltage decreases when the fractional effect increases. In cables with swellings we find that when the fractional effect or the swelling radius increase, the voltage decreases. A similar behavior is obtained when the number of swellings and the fractional effect increase. Moreover, we find that when the radius swelling (or the number of swellings) and the fractional effect increase at the same time, the voltage dramatically decreases.