Targeted and Imaging-guided In Vivo Photodynamic Therapy of Tumors Using Dual-functional, Aggregation-induced Emission Nanoparticles

TL;DR

This paper presents a novel dual-functional nanoparticle system that enables targeted, imaging-guided photodynamic therapy of tumors with high contrast and efficacy at low doses and light intensities, minimizing side effects.

Contribution

Introduction of aggregation-induced emission nanoparticles for combined tumor targeting, imaging, and photodynamic therapy with improved safety and effectiveness.

Findings

High contrast in in vivo tumor imaging

Effective tumor therapy at low nanoparticle doses

Minimal side effects due to low light intensity

Abstract

Dual-functional nanoparticles, with the property of aggregation-induced emission and the capability of reactive oxygen species, were used to achieve passive/active targeting of tumor. Good contrast in in vivo imaging and obvious therapeutic efficiency were realized with a low dose of AIE nanoparticles as well as a low power density of light, resulting in negligible side effects.