Long-time asymptotics for polymerization models

TL;DR

This paper analyzes the long-term behavior of polymerization models, revealing conditions under which polymers stabilize or fragment, with implications for biophysical fibrillation modeling.

Contribution

It extends classical models by incorporating nucleation, depolymerization, and fragmentation, showing how these processes influence long-term polymer stability.

Findings

Nucleation leads to trivial equilibrium with complete fragmentation.

Polymerization and fragmentation alone also result in trivial equilibrium.

Including depolymerization can stabilize the system and allow steady-state distributions.

Abstract

This study is devoted to the long-term behavior of nucleation, growth and fragmentation equations, modeling the spontaneous formation and kinetics of large polymers in a spatially homogeneous and closed environment. Such models are, for instance, commonly used in the biophysical community in order to model in vitro experiments of fibrillation. We investigate the interplay between four processes: nucleation, polymeriza-tion, depolymerization and fragmentation. We first revisit the well-known Lifshitz-Slyozov model, which takes into account only polymerization and depolymerization, and we show that, when nucleation is included, the system goes to a trivial equilibrium: all polymers fragmentize, going back to very small polymers. Taking into account only polymerization and fragmentation, modeled by the classical growth-fragmentation equation, also leads the system to the same trivial equilibrium, whether or not nucleation is considered. However, also taking into account a depolymer-ization reaction term may surprisingly stabilize the system, since a steady size-distribution of polymers may then emerge, as soon as polymeriza-tion dominates depolymerization for large sizes whereas depolymerization dominates polymerization for smaller ones-a case which fits the classical assumptions for the Lifshitz-Slyozov equations, but complemented with fragmentation so that " Ostwald ripening " does not happen.