Dictionary Learning and Sparse Coding-based Denoising for High-Resolution Task Functional Connectivity MRI Analysis

TL;DR

This paper introduces a novel denoising framework for task fMRI data using dictionary learning and sparse coding, leveraging task paradigm knowledge to enhance high-resolution brain connectivity analysis.

Contribution

It presents a new DLSC-based denoising method that incorporates prior task information, improving functional connectivity patterns in high-resolution tfMRI analysis.

Findings

Significantly improved connectivity pattern detection

Outperforms temporal non-local means denoising

Provides a better approach for fMRI preprocessing

Abstract

We propose a novel denoising framework for task functional Magnetic Resonance Imaging (tfMRI) data to delineate the high-resolution spatial pattern of the brain functional connectivity via dictionary learning and sparse coding (DLSC). In order to address the limitations of the unsupervised DLSC-based fMRI studies, we utilize the prior knowledge of task paradigm in the learning step to train a data-driven dictionary and to model the sparse representation. We apply the proposed DLSC-based method to Human Connectome Project (HCP) motor tfMRI dataset. Studies on the functional connectivity of cerebrocerebellar circuits in somatomotor networks show that the DLSC-based denoising framework can significantly improve the prominent connectivity patterns, in comparison to the temporal non-local means (tNLM)-based denoising method as well as the case without denoising, which is consistent and neuroscientifically meaningful within motor area. The promising results show that the proposed method can provide an important foundation for the high-resolution functional connectivity analysis, and provide a better approach for fMRI preprocessing.