# Quantitative Photoacoustic Imaging in the Acoustic Regime using SPIM

## TL;DR

This paper introduces a method for quantitative photoacoustic imaging that simultaneously reconstructs absorption, sound speed, and density in a medium using a generalized wave equation and SPIM techniques.

## Contribution

It presents analytical formulas for reconstructing multiple parameters in photoacoustic imaging based on a linearized model with SPIM, extending standard methods.

## Key findings

- Reconstruction formulas for absorption, sound speed, and density.
- Simultaneous imaging of multiple medium parameters.
- Extension of photoacoustic imaging capabilities.

## Abstract

While in standard photoacoustic imaging the propagation of sound waves is modeled by the standard wave equation, our approach is based on a generalized wave equation with variable sound speed and material density, respectively. In this paper we present an approach for photoacoustic imaging, which in addition to recovering of the absorption density parameter, the imaging parameter of standard photoacoustics, also allows to reconstruct the spatially varying sound speed and density, respectively, of the medium. We provide analytical reconstruction formulas for all three parameters based in a linearized model based on single plane illumination microscopy (SPIM) techniques.