Global generalized solutions to a parabolic-elliptic Keller-Segel system with singular sensitivity
Tobias Black

TL;DR
This paper establishes the existence of global generalized solutions for a Keller-Segel chemotaxis model with singular sensitivity in bounded domains, under specific conditions on the chemotactic sensitivity parameter and initial data.
Contribution
It introduces a notion of generalized solutions for the Keller-Segel system and proves their existence for a range of sensitivity parameters and initial data.
Findings
Existence of at least one global generalized solution for 0<χ<n/(n-2).
Generalized solutions are consistent with classical solutions when regularity conditions are met.
The results extend the understanding of chemotaxis models with singular sensitivities.
Abstract
We investigate the parabolic-elliptic Keller-Segel model \begin{align*}\left\{\begin{array}{r@{\,}l@{\quad}l@{\quad}l@{\,}c} u_{t}&=\Delta u-\,\chi\nabla\!\cdot(\frac{u}{v}\nabla v),\ &x\in\Omega,& t>0,\\ 0&=\Delta v-\,v+u,\ &x\in\Omega,& t>0,\\ \frac{\partial u}{\partial\nu}&=\frac{\partial v}{\partial\nu}=0,\ &x\in\partial\Omega,& t>0,\\ u(&x,0)=u_0(x),\ &x\in\Omega,& \end{array}\right. \end{align*} in a bounded domain with smooth boundary. \noindent We introduce a notion of generalized solvability which is consistent with the classical solution concept, and we show that whenever and the initial data satisfy only certain requirements on regularity and on positivity, one can find at least one global generalized solution.
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Global generalized solutions to a parabolic-elliptic Keller-Segel system with singular sensitivity
Tobias Black Institut für Mathematik, Universität Paderborn, Warburger Str. 100, 33098 Paderborn, Germany; email: [email protected]
Abstract
Abstract: We investigate the parabolic-elliptic Keller-Segel model
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in a bounded domain with smooth boundary.
We introduce a notion of generalized solvability which is consistent with the classical solution concept, and we show that whenever and the initial data satisfy only certain requirements on regularity and on positivity, one can find at least one global generalized solution.
Keywords: chemotaxis, global existence, logarithmic sensitivity, generalized solution
MSC (2010): 35K55, 35D99 (primary), 35A01, 35Q92, 92C17
1 Introduction
Since the introduction of the original parabolic-parabolic Keller–Segel model ([14])
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cross-diffusive systems of this type have been prototypical models for the description of the biological phenomenon of chemotaxis, a process of self-enhanced migration of cells towards higher concentration of a signal substance. For an overview of the biological background and related models in the context of chemotaxis we refer the reader to the surveys [11] and [12].
In this work we will consider a parabolic-elliptic Keller–Segel system with logarithmic sensitivity, as described by
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where , , is a bounded domain with smooth boundary and is a positive parameter. The singular sensitivity governing the cross-diffusive motion in the form featured in (1.5) expresses the model assumption that stimulus perception is governed by the Weber–Fechner law ([11],[19]). Both the parabolic-elliptic system and the parabolic-parabolic variant
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have been intensively studied in the last decades and a large amount of literature has been dedicated to the investigation of conditions ensuring the existence of time-global solutions in contrast to the possible occurrence of solutions blowing up in finite time. Nevertheless, for general dimensions the permissible strength of the sensitivity, as measured by the parameter , which allows for any solution stemming from reasonably regular initial data to exist globally, still remains mostly unclear even in the simple parabolic-elliptic setting of (1.5).
Let us briefly summarize some known results. In [18] Nagai and Senba studied radially symmetric solutions to (1.5) and showed that the classical radially symmetric solutions are global and bounded, whenever the conditions and , or and are fulfilled. On the other hand, if and they could prove the existence of solutions blowing up in finite time. In the studies independently undertaken in [2] under the condition the existence of global weak solutions was verified without any symmetry requirements, though the boundedness of the solutions was left open. Several years later this result was extended by proving that (1.5) possesses unique global bounded solutions if ([10]) and instead of even more general sensitivity functions satisfying have been investigated (cf. also [10]). More recently, the question concerning bounded classical solutions has been solved for the case of and the existence of finite time blow-up has been completely ruled out for any ([9]). In the corresponding parabolic-parabolic setting of (1.8) for suitably small , the results for two-dimensional domains do not differ significantly and still blow-up does not occur for any (cf. [8]). On the contrary when , the possible choices for are slightly more restricted. For instance, in [25] the global existence of classical solutions was established for and the boundedness of these solutions was later proven in [7] and recently generalized to sensitivity functions of the form with , and , for some possibly depending on the initial data when , by the studies in [17]. That is not the critical value in the parabolic-parabolic version of (1.5) is illustrated by the results of [15], where for global classical solutions were obtained for with some .
By weakening the solution concept, larger ranges for allowing for global solutions could be achieved in the setting of (1.8). Global weak solutions are known to exist for ([25]) and in even weaker concepts global generalized solutions exist for ([21]) or, as the most recent studies show, , atleast when or ([16]), highlighting once more the importance of the case as witnessed in the radial parabolic-elliptic setting of (1.5) in [18]. Since the result of [16] does not rely on any symmetry assumptions or largeness assumptions on the initial data, it seems reasonable to expect that in the simpler setting of (1.5) global generalized solutions may also exist for without requiring either radial symmetric initial data or .
Main results. Our main purpose in this work is to introduce a concept of generalized solvability for (1.5), which on one hand is consistent with the concept of classical solvability and on the other hand is weak enough to allow for the construction of global solutions for , without requiring any symmetry assumption on the initial data. To be precise, we will only assume the initial data to satisfy
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Under this assumption our main result can be stated as follows.
Theorem 1.1.
Let and be a bounded domain with smooth boundary. Suppose that
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then for any satisfying (1.9), the problem (1.5) possesses at least one global generalized solution in the sense of Definition 2.1 below. Furthermore, this solution satisfies
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2 Generalized solution concept
Concepts of generalized solvability in related settings have previously been studied in e.g. [26], [16], [27], or [3]. The requirements imposed on the solution components in these concepts can often be viewed as generalizations of a classical supersolution properties combined with suitable regularity conditions giving meaning to the integral inequality prescribed. In the current setting the generalized solutions we will investigate will fulfill such a supersolution property for the quantity , whereas for we will require the standard weak solution concept with everything made precise by the following definition.
Definition 2.1.
Suppose that
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are such that and a.e. in . Then will be called a global generalized solution of (1.5) if there exists such that
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and such that the inequality
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holds for each nonnegative such that on , if moreover the identity
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is valid for any , and if satisfies
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as well as
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Let us now make sure that the above concept of solvability is consistent with the classical one, meaning that a generalized solution of (1.5), which is smooth enough, is also a classical solution of (1.5). In particular the a.e. positivity of on will play a crucial role in making sure that satisfies its equation in the classical sense. The proof builds on ideas previously used in [26, Lemma 2.1] and [16, Lemma 2.5].
Lemma 2.2.
Let and assume that (u,v)\in\Big{(}C^{0}\!\left(\operatorname{\overline{\Omega}}\times[0,\infty)\right)\cap C^{2,1}\!\left(\operatorname{\overline{\Omega}}\times(0,\infty)\right)\Big{)}\times C^{2,0}\!\left(\operatorname{\overline{\Omega}}\times(0,\infty)\right) is a global generalized solution of (1.5) in the sense of Definition 2.1. Then solves (1.5) in the classical sense in .
Proof:.
In light of the assumed regularity properties of it can be easily verified by standard arguments that is a classical solution to the second equation in (1.5) with the prescribed initial and boundary data and we may focus on proving that is a classical solution of the first equation in (1.5) for the remainder of the proof. Given an arbitrary nonnegative satisfying \frac{\partial\psi}{\partial\nu}\big{|}_{\operatorname{\partial\Omega}}=0, for we define , and plug into (2.1) to see upon taking that
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in view of Lebesgue’s dominated convergence theorem and the continuity of at . This readily establishes in , which in combination with the continuity of at and (2.8) shows in .
Due to terms of the form appearing when we integrate by parts we will now only consider test functions which are compactly supported in . Consequently, for any nonnegative with and \frac{\partial\varphi}{\partial\nu}\big{|}_{\operatorname{\partial\Omega}}=0 integrating by parts in the second and last integrals on the right in (2.1) shows that
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since on . Now, straightforward calculations show that
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and thus, we may rewrite (2) as
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for any nonnegative with and \frac{\partial\varphi}{\partial\nu}\big{|}_{\operatorname{\partial\Omega}}=0, since we already know that solves the second equation in (1.5). Restricting to nonnegative we may rely on a Du Bois-Reymond lemma type argument to conclude that
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In view of the continuity of and the fact that a.e. in , (2.11) actually holds in all of .
In order to first see that on we refer the reader to the proof of [16, Lemma 2.5] for a detailed construction of suitable permissible test functions in (2) and remark here only that it is essential to ensure that the support of the test functions intersects the boundary only in points where is positive. Lastly, to show that fulfills the homogeneous Neumann boundary condition and that (2.11) is actually an equality, we integrate (2.11) over and make use of (2.8) to see that
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in view of Gauss’ theorem and the fact that on . This shows that actually on and in turn proves that (2.11) is an equality, implying that solves the first equation of (1.5) in the classical sense. ∎
3 Approximate solutions and basic properties
The construction of a global generalized solution is based on a limit procedure of solutions to suitably regularized problems. We will therefore continue by investigating approximate problems which for take the form
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3.1 Local existence and first estimates independent of
Lemma 3.1.
Let , and suppose that satisfies (1.9). Then there exists a maximal existence time and a unique pair of nonnegative functions
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solving the problem (3.5) in the classical sense. Moreover,
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Proof:.
The local existence of classical solutions on and an extensibility criterion can be proven by relying on well-known fixed point arguments as displayed for a very closely related setting in [10, Proposition 3.1] (or [1, Lemma 3.1] for a parabolic-parabolic variant), while making use of the facts that and that is strictly positive on (see Lemma 3.3 below). ∎
In the sequel of the paper we will always assume that the initial data satisfy (1.9), and for we let denote the corresponding solution to (3.5) given by Lemma 3.1. We will first focus our efforts on proving that these local solutions are in fact global solutions to (3.5). As a starting point for further a priori estimates we obtain the following – regularity result for the approximate solutions.
Lemma 3.2.
Let and . Then
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Proof:.
The first asserted identity immediately follows from integration of the first equation in (3.5). Making use of the established mass conservation, an integration of the second equation in (3.5) consequently proves the second equality. ∎
Another important property of the solutions to the approximate problems is a pointwise lower bound – strictly larger than zero – for the component , which can be shown by an estimation of the fundamental solution from below. Arguments of this in this spirit have previously been employed in e.g. [10, Lemma 2.1] and [17, Lemma 2.1].
Lemma 3.3.
There exists such that for each ,
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Proof:.
Making use of the positivity of the fundamental solution of the heat equation (e.g. [13, Chapter 10]), one can find such that for all nonnegative we have
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Now, we can make use of the representation of resolvents via semigroups and Lemma 3.2 to obtain
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for all and all . ∎
Additionally, we can make use of standard elliptic theory to slightly improve our a priori knowledge on the regularity of .
Lemma 3.4.
Let be such that and . Then there exists such that for all we have
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and
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Proof:.
According to known results concerning elliptic boundary-value problems with inhomogeneities in (see e.g. [5]) one can find such that
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In view of the second equation and Lemma 3.2 this yields
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proving (3.8). This bound at hand, (3.7) follows from the Sobolev embedding theorem, since for all we can pick some such that . ∎
In addition to the regularity provided by the previous result, we can also make rely on the strict positivity of to obtain the following a priori bound in a straightforward manner.
Lemma 3.5.
Let . Then
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Proof:.
In view of the strict positivity of established by Lemma 3.3, we may use as a test function in the second equation of (3.5) and obtain upon integration by parts that
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Due to the positivity of both and , the assertion immediately follows upon dropping the integral containing . ∎
3.2 Global solvability of the approximate problems
Relying on the lower bound of , the fact that holds for all and standard elliptic theory, we will make use of an iterative argument to improve the regularity of and to a level where semigroup arguments for the heat semigroup become applicable to provide the boundedness of , which in view of the extensibility criterion is sufficient to conclude that .
Lemma 3.6.
Let and , and let denote the local classical solution of (3.5) in obtained in Lemma 3.1. Then .
Proof:.
Suppose . For , by using integration by parts and Young’s inequality we compute
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with . Employing Young’s inequality once more and making use of Lemma 3.3 and the fact that for all we obtain that
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with and with given by Lemma 3.3. Furthermore, by standard elliptic theory (e.g. [4, Theorem 9.32]) there exists such that
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since , and combination with (3.9) shows that
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with C_{4}=q\big{(}1+\frac{C_{2}C_{3}}{\varepsilon^{q}K_{1}^{q}}\big{)}>0, implying that for any we have for all with some . Relying on (3.10) once more, we also see that with some , due to the Sobolev embedding theorem. Thus, making use of a Moser type iteration (e.g. [22, Lemma A.1]) we obtain for all with some , contradicting the extensibility criterion (3.6) and thereby proving that . ∎
4 Construction of limit functions
In the next section we will derive a fundamental inequality for the approximate systems (3.5). Relying on the fairly arbitrary choices possible for the test functions used therein, we will then first apply this to (see Lemma 4.2) to derive a set of crucial a priori estimates. Later on (see proof of Theorem 1.1) we will make use of this inequality to verify the supersolution property featured in (2.1) of Definition 2.1.
4.1 Precompactness properties
Before we start with the derivation of the fundamental inequality, let us introduce the following notation. For and we define
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Let us also remark here that obviously for all and that for we have , as these are two properties we will require later on.
Lemma 4.1.
Let , , and . Assume that satisfies on . Then the classical solution of (3.5) in satisfies
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Proof:.
We start using the first equation of (3.5) and multiple integrations by parts to compute
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where we rewrote . Integrating the integral containing once more by parts, relying on the second equation of (3.5) to express and making use of the fact that for all we have for all , we see that
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holds for all . Now, to get rid of the term quadratic in , we test the second equation in (3.5) with – which again due to Lemma 3.3 is an admissible test function – and integrate by parts to obtain
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for all , which by rewriting implies
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Decomposing the integral containing the mixed derivatives in the same manner as in the proof of Lemma 2.2, we see that this readily implies
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for all . Finally, a combination of (4.1)–(4.1) completes the proof upon integration over . ∎
As an immediate consequence of the differential inequality provided by the preceding lemma we obtain the following spatio-temporal estimates for suitable values of .
Lemma 4.2.
For let p\in\big{(}0,1) satisfy . Then for each there exists such that
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and
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as well as
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and
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for all .
Proof:.
By an application of Lemma 4.1 to , by the positivity of we see that
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holds for all . Due to and , this immediately implies (4.6)–(4.8) in view of Lemma 3.2. To see that also (4.9) holds, we make use of the strict positivity of ensured in Lemma 3.3 and test the second equation with to obtain that
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holds for all and all . Thus, integrating over , rewriting and applying Young’s inequality shows that
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which readily implies (4.9) in view of (4.6) and combined with Lemma 3.2. ∎
The boundedness information on obtained in the previous lemma is the crucial ingredient in improving the regularity of . Here must not be too small leading to the main reason for the restriction .
Lemma 4.3.
For let satisfy . Then there exists some such that for any there exists such that
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Proof:.
Given and such that we can fix satisfying and make use of Young’s inequality to find such that
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holds for all . Since implies , we can make use of Lemma 3.4 and (4.8) to find and satisfying
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4.2 Time regularity of
In pursuance of convergence properties suitable for our definition of generalized solutions we will rely on an Aubin-Lions type lemma for which we will require some additional information on the time regularity of our approximate solutions. We will therefore make use of some of the previously established a priori estimates to supplement our current repertoire of estimates with the following lemma.
Lemma 4.4.
Assume and let satisfy . Then for all there exists such that
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Proof:.
For fixed such that we make use of the first equation in (3.5) and integration by parts to obtain
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for all and . Having in mind the obvious estimates , , and in , we can draw on the fact that and Young’s inequality to see that
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holds for all and . Since , for all and we have that
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in view of Lemma 3.2, whereas Lemma 3.5 shows that
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Thus, a combination of these three estimates with (4.2) provides such that for all ,
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which in conjunction with (4.6) of Lemma 4.2 completes the proof upon an integration over . ∎
4.3 Convergence properties
From the above estimates we can now extract a subsequence along which we may pass to the limit in a way suitable for our setting.
Lemma 4.5.
Assume and let satisfy . Then there exist and functions and defined on such that as , that and a.e. in , and that
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as . Moreover,
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Proof:.
Intending to employ an Aubin-Lions type argument to obtain a first convergence information for , we fix any such that and combine Lemma 4.2 with Lemma 3.2 and Lemma 4.4 to find that
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and that
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Hence, we can invoke an Aubin-Lions lemma ([20, Corollary 8.4]) to infer the existence of such that as , that
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and such that (4.13) holds with some nonnegative function defined on . Now, relying on the a.e. convergence of and the equi-integrability property of for some small contained in Lemma 4.3 we may employ the Vitali convergence theorem to find
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implying that also (4.12) holds, whereupon (4.17) follows from Lemma 3.2. Since from standard elliptic theory (e.g. [4, Theorem 9.32]) we know that for all and all we have with , (4.19) readily implies that there exists some nonnegative defined on such that (4.14) holds. For proving (4.15) we pick such that still holds and see that by Lemma 4.2 there exists such that with taken from Lemma 3.3 we have
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for all . Hence, an application of the Vitali convergence theorem proves (4.15). To verify (4.16), we first note that in view of (4.9) there exists some such that (upon choice of a suitable subsequence)
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Furthermore, due to (4.18) we have in and in in light of the precompactness property implied by Lemma 3.5, and thus
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which ensures that a.e. in , and due to (4.20) hence shows (4.16). ∎
5 Proof of Theorem 1.1
In order to verify the crucial positivity properties demanded in the Definition 2.1 we want to find some lower bound for . To this end we will state two technical lemmas which have been proven in [16] and prepare a comparison argument for a differential inequality.
Lemma 5.1.
Let , , and let be a continuously differentiable function satisfying
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Then
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Proof:.
We refer the reader to [16, Lemma 8.3] for the proof. ∎
In addition to the previous comparison lemma we will also make use of the following auxiliary lemma which was given in [16, Lemma 8.4] – generalizing a result proven in [23, Lemma 4.3] to non-convex domains.
Lemma 5.2.
Let . Then there exists such that every positive function fulfilling
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for some satisfies
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Proof:.
This is [16, Lemma 8.4]. ∎
Relying on the previous two lemmata we can now build on the ideas from [16, Lemma 8.5] obtain the following.
Lemma 5.3.
There exists such that for every the inequality
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is valid.
Proof:.
For and we let . Picking , we obtain from standard elliptic regularity theory that for all with some and hence, by the Sobolev embedding theorem, that
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Invoking the well-known smoothing estimates for the Neumann heat semigroup (e.g. [6, Lemma 2.1] or [24, Lemma 1.3]) we find such that
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for all and all , with given by Lemma 3.3. From this we infer the existence of such that
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which, in view of the fact that for all and the inequality
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holds true, implies that
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Letting we see that certainly
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so that for all we may estimate
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Now, since for and we have
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we conclude for every and each , so that from Lemma 5.2 we obtain some such that a combination of Lemma 5.2 with Lemma 3.5 shows that
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for every where . Therefore, an application of Lemma 5.1 completes the proof. ∎
The three preceding lemmas at hand we can now emulate the arguments featured in [16, Lemma 8.6] to verify the essential positivity requirements appearing in Definition 2.1.
Lemma 5.4.
Assume and let be such that . Then the functions and obtained in Lemma 4.5 satisfy , and a.e. in as well as a.e. on .
Proof:.
The positivity of a.e. in follows from Lemma 3.3 and (4.14). For the positivity of a.e. in and a.e. on we start by calculating
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for all . Now, for fixed in view of Lemma 5.3 we can find such that
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which together with Lemma 3.5 shows upon integration of (5.1) that for any fixed we have
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for all , with the right-hand side being bounded independently of by virtue of (5.2). Relying on the basic estimate for all , we can first make use of Lemma 3.2 and (5.3) to find such that for all . Afterwards, we invoke the Poincaré inequality to find such that for all and conclude, again by (5.3), that for every and there exists such that
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In view of a weak compactness argument this means that we actually have , which readily entails and also by a trace embedding theorem and thus proves the asserted positivity properties. ∎
Most of the requirements appearing in Definition 2.1 are prepared and all that is left is to combine the information presented in Lemma 5.1, Lemma 4.5 and Lemma 5.4.
Proof of Theorem 1.1:.
We fix such that , which in particular means that the requirements for Lemma 4.5 and Lemma 5.4 are satisfied. The regularity properties prescribed in (2.1) are satisfied according to (4.12), (4.14) and the regularity requirements featured in (2.5) are fulfilled in view of (4.13), (4.15), and (4.16). The positivity properties have been shown in Lemma 5.4, whereas the mass identity (1.10) is valid due to (4.17). Since for all and arbitrary the global classical solution of (3.5) satisfies
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we see that due to (4.12) and (4.14) we may let in each integral and obtain that (2.7) holds and the only thing left is to verify (2.1). To this end, we fix a nonnegative satisfying on and such that in . Invoking Lemma 4.1 shows that with as introduced in (4.1),
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Relying on the facts that and for all we see that by (4.12) we have
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as , whereas (4.15) shows that
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as . For the three integrals containing the spatial derivative of we note that \frac{u_{\varepsilon}^{p}}{v_{\varepsilon}}\nabla v_{\varepsilon}=\Big{(}u_{\varepsilon}^{\frac{p}{2}}\Big{)}\cdot\Big{(}\frac{u_{\varepsilon}^{\frac{p}{2}}}{v_{\varepsilon}}\nabla v_{\varepsilon}\Big{)}, which according to (4.12) and (4.16) implies
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as . Finally, by the lower semicontinuity of the norm in with respect to weak convergence it follows from (4.13) and (4.16) that
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so that passing to the limit each of the integrals in (5) yields
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proving (2.1), and thereby verifies that indeed is a global generalized solution in the sense of Definition 2.1. ∎
Acknowledgements
The author acknowledges support of the Deutsche Forschungsgemeinschaft in the context of the project Analysis of chemotactic cross-diffusion in complex frameworks.
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