# Crystallization via tubing microfluidics permits both in situ and ex situ X-ray diffraction

## TL;DR

This paper presents a microfluidic platform that enables efficient crystallization and handling of pharmaceutical proteins for X-ray diffraction, allowing in situ and ex situ data collection to improve crystal quality and analysis.

## Contribution

The study introduces a novel microfluidic approach for protein crystallization that simplifies crystal handling and enhances diffraction data collection.

## Key findings

- Optimized crystallization conditions for a pharmaceutical protein.
- Achieved high-quality diffraction data both in situ and ex situ.
- Demonstrated the effectiveness of microfluidics in protein crystallography.

## Abstract

We used a microfluidic platform to address the problems of obtaining diffraction quality crystals and crystal handling during transfer to the X-ray diffractometer. We optimize crystallization conditions of a pharmaceutical protein and collect X-ray data both in situ and ex situ.

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Source: https://tomesphere.com/paper/1704.06301