# Kinetic model of selectivity and conductivity of the KcsA filter

## TL;DR

This paper presents a kinetic model for the KcsA potassium channel that explains its high selectivity and conductivity by considering detailed energy interactions, fitting well with experimental data.

## Contribution

It introduces a self-consistent multi-species kinetic theory incorporating energy spectrum contributions, including dehydration and Coulomb effects, to model ion selectivity and conductance.

## Key findings

- Model captures high selectivity and fast conductivity
- Fits well with experimental data
- Reveals Coulomb blockade phenomena in ion transport

## Abstract

We introduce a self-consistent multi-species kinetic theory based on the structure of the narrow voltage-gated potassium channel. Transition rates depend on a complete energy spectrum with contributions including the dehydration amongst species, interaction with the dipolar charge of the filter and, bulk solution properties. It displays high selectivity between species coexisting with fast conductivity, and Coulomb blockade phenomena, and it fits well to data.