Experimental determination of the frequency and field dependence of Specific Loss Power in Magnetic Fluid Hyperthermia

TL;DR

This study experimentally investigates how the Specific Loss Power of magnetic nanoparticles varies with frequency, field strength, and particle size, confirming size-dependent heating mechanisms relevant for magnetic hyperthermia therapy.

Contribution

It provides new experimental data on the size and field dependence of SLP in maghemite ferrofluids, validating the Linear Response Theory model for specific conditions.

Findings

SLP depends on core size, frequency, and field strength.

The relationship SLP=cH^x with 2<x<3 is established.

Effective relaxation time matches theoretical estimates for smallest particles.

Abstract

Magnetic nanoparticles are promising systems for biomedical applications and in particular for Magnetic Fluid Hyperthermia, a promising therapy that utilizes the heat released by such systems to damage tumor cells. We present an experimental study of the physical properties that influences the capability of heat release, i.e. the Specific Loss Power, SLP, of three biocompatible ferrofluid samples having a magnetic core of maghemite with different core diameter d= 10.2, 14.6 and 19.7 nm. The SLP was measured as a function of frequency f and intensity of the applied alternating magnetic field H, and it turned out to depend on the core diameter, as expected. The results allowed us to highlight experimentally that the physical mechanism responsible for the heating is size-dependent and to establish, at applied constant frequency, the phenomenological functional relationship SLP=cH^x, with 2<x<3 for all samples. The x-value depends on sample size and field frequency/ intensity, here chosen in the typical range of operating magnetic hyperthermia devices. For the smallest sample, the effective relaxation time Teff=19.5 ns obtained from SLP data is in agreement with the value estimated from magnetization data, thus confirming the validity of the Linear Response Theory model for this system at properly chosen field intensity and frequency.