Multiscale fabrication of scalable biomimetic 3-D, integrated micro-nanochannels network in PDMS for solute exchange

TL;DR

This paper presents a scalable hybrid microfabrication method combining 3D printing and electrospinning to create biomimetic 3D micro-nanochannel networks in PDMS for efficient solute exchange, mimicking natural vasculature.

Contribution

It introduces a novel, scalable fabrication process integrating micro and nanotechnologies to produce complex micro-nanochannel networks in PDMS, overcoming limitations of traditional methods.

Findings

Successfully fabricated biomimetic micro-nanochannel networks in PDMS.

Demonstrated efficient fluid flow and solute exchange in the device.

Potential applications in biomedical and diagnostic microfluidic devices.

Abstract

Integrated micro-nanochannel networks in fluidic devices are desirable in a number of applications ranging from self-healing/cooling materials to bioengineering. The conventional micro-manufacturing techniques are capable of either producing microchannel or nanochannel networks for a fluidic application but lack proficiency in the production of an integrated micro-nanochannel network with a smooth transition from micro-to-nano scale dimension. In addition, these techniques possess limitations such as heavy initial investment, sophistication in operation and scale-up capabilities. Therefore, the current paper demonstrates the combination of micro/nanotechnologies to design and develop a biomimetic 3-D integrated micro-nanochannel network in PDMS device for solute exchange. We have used 3-D printer, a scalable technology, to design and manufacture micro-mold having fractal-shaped features. Further, electrospinning was used to deposit nanofibrous network on the fractal mold. Subsequent micro-molding with PDMS was used to obtain fractal-shaped microchannels integrated with embedded nanofibers. Henceforth, solvent etching of nanofibers followed by bonding of thin PDMS membrane generated by spin coating to open end of channels leads to the formation of functional microdevices. These PDMS devices mimic the natural vasculature of a living system, where fractal-shaped microchannels will assist in efficient fluid flow and the site of nanovascular network participates in heat/mass transport operations. Further, dye flow propounds the functionality of such devices. Our study hence proposes a simple and scalable hybrid microtechnolgy to fabricate fluidic devices having multiscale architecture. This will also facilitate the rapid fabrication of microfluidic devices for biomedical, diagnostics, sensors and micro-TAS applications.