# Interference of two co-directional exclusion processes in the presence of a static bottleneck: a biologically motivated model

## TL;DR

This study models the interference of two co-directional exclusion processes with a static bottleneck, revealing how bottleneck strength influences flow regulation and phase behavior, with implications for biological transport phenomena.

## Contribution

Introduces a two-species exclusion process with a static bottleneck, analyzing flow interference and phase behavior using mean-field theory and simulations, inspired by biological systems.

## Key findings

- Flow suppression can be controlled by bottleneck strength.
- Certain phases become unrealizable under stringent bottlenecks.
- Flow regulation between species is influenced by bottleneck properties.

## Abstract

We develope a two-species exclusion process with a distinct pair of entry and exit sites for each species of rigid rods. The relatively slower forward stepping of the rods in an extended bottleneck region, located in between the two entry sites, controls the extent of interference of the co-directional flow of the two species of rods. The relative positions of the sites of entry of the two species of rods with respect to the location of the bottleneck are motivated by a biological phenomenon. However, the primary focus of the study here is to explore the effects of the interference of the flow of the two species of rods on their spatio-temporal organization and the regulations of this interference by the extended bottleneck. By a combination of mean-field theory and computer simulation we calculate the flux of both species of rods and their density profiles as well as the composite phase diagrams of the system. If the bottleneck is sufficiently stringent some of the phases become practically unrealizable although not ruled out on the basis of any fundamental physical principle. Moreover the extent of suppression of flow of the downstream entrants by the flow of the upstream entrants can also be regulated by the strength of the bottleneck. We speculate on the possible implications of the results in the context of the biological phenomenon that motivated the formulation of the theoretical model.