Murburn concept: A facile explanation for oxygen-centered cellular respiration

TL;DR

The paper introduces the murburn concept as a new paradigm explaining oxygen-centered cellular respiration, challenging traditional models by emphasizing reactive oxygen species' role in mitochondrial ATP synthesis.

Contribution

It proposes that diffusible reactive oxygen species are central to mitochondrial respiration, offering a novel explanation that departs from established biochemical paradigms.

Findings

Debunked traditional mitochondrial oxidative phosphorylation explanations.

Proposed the inner mitochondrial membrane stabilizes radical reactions for ATP synthesis.

Suggested reactive oxygen species are fundamental to cellular metabolism.

Abstract

Via a concomitant communication (the first part of my work), I have conclusively debunked the prevailing explanations for mitochondrial oxidative phosphorylation and established the need for a novel rationale to account for the reaction paradigm. Towards the same, murburn concept is hereby floated as a viable explanation (in the second part of my work). It is proposed that the inner mitochondrial membrane (harboring the various metal and flavin enzyme complexes) serves as means to confine and stabilize radical reactions, which effectively couple and bring about ATP synthesis in the proton-deficient microcosm. The proposed scheme is un-ordered and favored by Ockham's razor and evolutionary perspectives. Murburn concept is a paradigm-shift in biochemistry because it advocates that diffusible reactive (oxygen) species are mainstay of routine cellular metabolic process within the mitochondria.