# ceRNA crosstalk stabilizes protein expression and affects the correlation pattern of interacting proteins

## TL;DR

This paper shows through simulations and modeling that miRNA-mediated crosstalk between mRNAs stabilizes protein levels and alters correlation patterns of interacting proteins, revealing a new layer of gene regulation.

## Contribution

It introduces a novel concept that miRNA-induced competition causes widespread protein stabilization and changes in protein correlation patterns, extending beyond traditional noise buffering.

## Key findings

- miRNA crosstalk stabilizes protein levels across gene expression ranges
- It changes correlation patterns of co-regulated proteins from negative to positive
- RNA crosstalk signatures can be detected in standard cellular conditions

## Abstract

Gene expression is a noisy process and several mechanisms, both transcriptional and posttranscriptional, can stabilize protein levels in cells. Much work has focused on the role of miRNAs, showing in particular that miRNA-mediated regulation can buffer expression noise for lowly expressed genes. Here, using in silico simulations and mathematical modeling, we demonstrate that miRNAs can exert a much broader influence on protein levels by orchestrating competition-induced crosstalk between mRNAs. Most notably, we find that miRNA-mediated cross-talk (i) can stabilize protein levels across the full range of gene expression rates, and (ii) modifies the correlation pattern of co-regulated interacting proteins, changing the sign of correlations from negative to positive. The latter feature may constitute a potentially robust signature of the existence of RNA crosstalk induced by endogenous competition for miRNAs in standard cellular conditions.

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Source: https://tomesphere.com/paper/1703.02758