# Cell survival probability in a spread-out Bragg peak for novel treatment planning

## TL;DR

This paper addresses the challenge of variable cell survival probability in spread-out Bragg peaks for ion-beam therapy, proposing a multiscale physics-based approach to improve treatment planning and optimization.

## Contribution

It introduces a novel multiscale method to understand and solve the cell survival variability problem in ion-beam therapy planning.

## Key findings

- Quantitative analysis of physical causes of survival probability variation
- A proposed recipe for treatment planning optimization
- Foundation for science-based ion-beam therapy design

## Abstract

The problem of variable cell survival probability along the spread-out Bragg peak is one of the long standing problems in planning and optimisation of ion-beam therapy. This problem is considered using the multiscale approach to the physics of ion-beam therapy. The physical reasons for this problem are analysed and understood on a quantitative level. A recipe of solution to this problem is suggested using this approach. This recipe can be used in the design of a novel treatment planning and optimisation based on fundamental science.