# Force-detected Nuclear Magnetic Resonance

## TL;DR

Force-detected NMR is a highly sensitive technique that enhances NMR detection by using force measurement, enabling 3D MRI at nanometer resolution and showing promising future improvements.

## Contribution

This paper reviews the principles, history, and recent advancements of force-detected NMR, highlighting its application in high-resolution 3D MRI at the nanoscale.

## Key findings

- Demonstrated 3D NMR imaging with nanometer resolution.
- Reviewed recent developments and potential improvements.
- Compared force-detected NMR with other detection technologies.

## Abstract

The drive to improve the sensitivity of nuclear magnetic resonance (NMR) to smaller and smaller sample volumes has led to the development of a variety of techniques distinct from conventional inductive detection. In this chapter, we focus on the technique of force-detected NMR as one of the most successful in yielding sensitivity improvements. We review the rationale for the technique, its basic principles, and give a brief history of its most important results. We then cover in greater detail its application in the first demonstration of three-dimensional (3D) nuclear magnetic resonance imaging (MRI) with nanometer-scale resolution. Next we present recent developments and likely paths for improvement. Finally, the technique and its potential are discussed in the context of competing and complementary technologies.

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Source: https://tomesphere.com/paper/1702.06566