Real-time fMRI neurofeedback of the mediodorsal and anterior thalamus enhances correlation between thalamic BOLD activity and alpha EEG rhythm

TL;DR

This study demonstrates that real-time fMRI neurofeedback targeting the thalamus can enhance the correlation between thalamic activity and alpha EEG rhythms, revealing new insights into brain connectivity and neuromodulation.

Contribution

It introduces a novel approach combining real-time fMRI neurofeedback with EEG to modulate and study thalamic and cortical activity correlations in humans.

Findings

Participants learned to upregulate thalamic BOLD activity.

Enhanced functional connectivity between thalamus and precuneus.

Significant increase in correlation between alpha EEG power and thalamic activity.

Abstract

Real-time fMRI neurofeedback (rtfMRI-nf) with simultaneous EEG allows volitional modulation of BOLD activity of target brain regions and investigation of related electrophysiological activity. We applied this approach to study correlations between thalamic BOLD activity and alpha EEG rhythm. Healthy volunteers in the experimental group (EG, n=15) learned to upregulate BOLD activity of the target region consisting of the mediodorsal (MD) and anterior (AN) thalamic nuclei using the rtfMRI-nf during retrieval of happy autobiographical memories. Healthy subjects in the control group (CG, n=14) were provided with a sham feedback. The EG participants were able to significantly increase BOLD activities of the MD and AN. Functional connectivity between the MD and the inferior precuneus was significantly enhanced during the rtfMRI-nf task. Average individual changes in the occipital alpha EEG power significantly correlated with the average MD BOLD activity levels for the EG. Temporal correlations between the occipital alpha EEG power and BOLD activities of the MD and AN were significantly enhanced, during the rtfMRI-nf task, for the EG compared to the CG. Temporal correlations with the alpha power were also significantly enhanced for the posterior nodes of the default mode network, including the precuneus/posterior cingulate, and for the dorsal striatum. Our findings suggest that the temporal correlation between the MD BOLD activity and posterior alpha EEG power is modulated by the interaction between the MD and the inferior precuneus, reflected in their functional connectivity. Our results demonstrate the potential of the rtfMRI-nf with simultaneous EEG for non-invasive neuromodulation studies of human brain function.