# Kinetics of the Phospholipid Multilayer Formation at the Surface of the Silica Sol

## TL;DR

This study investigates the formation kinetics of DSPC phospholipid multilayers on silica sol surfaces using X-ray reflectometry, revealing how silica nanoparticles accelerate bilayer saturation and influence multilayer structure.

## Contribution

It introduces a model-independent method to analyze multilayer formation and demonstrates the effect of silica nanoparticles on bilayer saturation dynamics.

## Key findings

- Bilayer saturation with Na+ and H2O is accelerated by silica nanoparticles.
- Multilayer formation time is approximately 10^5 to 7x10^5 seconds.
- The multilayer exhibits about 13% excess electron density.

## Abstract

The ordering of a multilayer consisting of DSPC bilayers on a silica sol substrate is studied within the model-independent approach to the reconstruction of profiles of the electron density from X-ray reflectometry data. It is found that the electroporation of bilayers in the field of anion silica nanoparticles significantly accelerates the process of their saturation with Na+ and H2O, which explains both a relatively small time of formation of the structure of the multilayer of 10^5 - 7x10^5 s and ~13 % excess of the electron density in it.