Structural characterization of magnetoferritin
Lucia Meln\'ikov\'a, Zuzana Mitr\'oov\'a, Milan Timko, Jozef, Kov\'a\v{c}, Mikhail V. Avdeev, Viktor I. Petrenko, Vasyl M. Garamus,, L\'aszl\'o Alm\'asy, Peter Kop\v{c}ansk\'y
TL;DR
This study provides a detailed physicochemical analysis of magnetoferritin, demonstrating efficient iron oxide loading into apoferritin while maintaining its biocompatible structure and altering the protein shell's morphology.
Contribution
It offers new insights into the structural and magnetic properties of magnetoferritin, highlighting its potential for biomedical applications.
Findings
Iron oxides can be loaded into apoferritin efficiently.
Loading preserves the biocompatible structure of apoferritin.
Loading affects the morphology of the protein shell.
Abstract
The physicochemical characterization of the magnetoferritin biomacromolecule in terms of morphology, structural and magnetic properties shows that iron oxides can be efficiently loaded into apoferritin molecules, preserving their native biocompatible structure and affecting the morphology of the protein shell.
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