A generalized solution concept for the Keller-Segel system with logarithmic sensitivity: Global solvability for large nonradial data
Johannes Lankeit, Michael Winkler

TL;DR
This paper introduces a new generalized solution framework for the Keller-Segel chemotaxis system with logarithmic sensitivity, extending global solvability results to larger parameter ranges and nonradial initial data.
Contribution
A novel generalized solution concept is developed, allowing for extended parameter ranges and nonradial data in the Keller-Segel system with logarithmic sensitivity.
Findings
Global solutions exist for a broader range of the chemotactic sensitivity parameter under the new framework.
The solutions are well-defined for large, nonradial initial data with certain regularity and positivity.
The solutions have local integrability properties in space-time.
Abstract
The chemotaxis system \[ \left\{ \begin{array}{l} u_t = \Delta u - \chi\nabla \cdot (\frac{u}{v}\nabla v), v_t=\Delta v - v+u, \end{array} \right. \] is considered in a bounded domain with smooth boundary, where . An apparently novel type of generalized solution framework is introduced within which an extension of previously known ranges for the key parameter with regard to global solvability is achieved. In particular, it is shown that under the hypothesis that\[ \chi < \left\{ \begin{array}{ll} \infty \qquad & \mbox{if } n=2, \sqrt{8} \qquad & \mbox{if } n=3, \frac{n}{n-2} \qquad & \mbox{if } n\ge 4, \end{array} \right. \] for all initial data satisfying suitable assumptions on regularity and positivity, an associated no-flux initial-boundary value problem admits a globally defined generalized solution. This solution inter alia has the…
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Taxonomy
TopicsMathematical Biology Tumor Growth · Gene Regulatory Network Analysis · Cancer Genomics and Diagnostics
