# Effect of fractional blood flow on plasma skimming in the microvasculature

## TL;DR

This paper introduces a new plasma skimming model that incorporates fractional blood flow effects at vessel bifurcations, validated against in vivo data and microvascular network simulations, revealing an exponential decay pattern of the plasma skimming parameter.

## Contribution

A novel plasma skimming model that accounts for fractional blood flow, improving the understanding of red blood cell redistribution in microvasculature.

## Key findings

- Exponential decay of plasma skimming parameter with fractional flow rate.
- Model aligns well with in vivo and network simulation data.
- Enhanced quantitative description of blood flow redistribution.

## Abstract

Although redistribution of red blood cells at bifurcated vessels is highly dependent on flow rate, it is still challenging to quantitatively express the dependency of flow rate in plasma skimming due to nonlinear cellular interactions. We suggest a plasma skimming model that can involve the effect of fractional blood flow at each bifurcation point. For validating the new model, it is compared with \textit{in vivo} data at single bifurcation points, as well as microvascular network systems. In the simulation results, the exponential decay of plasma skimming parameter, $M$, along fractional flow rate shows the best performance in both cases.