# Luria-Delbruck, revisited: The classic experiment does not rule out Lamarckian evolution

## TL;DR

This paper re-analyzes the classic Luria-Delbruck experiment using Bayesian methods, showing it supports Darwinian evolution but does not exclude the possibility of Lamarckian mechanisms contributing to evolution.

## Contribution

It introduces a Bayesian model selection approach to re-evaluate the classic experiment, considering combined Darwinian and Lamarckian models.

## Key findings

- Supports Darwinian evolution over pure Lamarckian model
- Does not rule out Lamarckian contributions in evolution
- Revises interpretation of classic experiment with Bayesian analysis

## Abstract

We re-examined data from the classic Luria-Delbruck fluctuation experiment, which is often credited with establishing a Darwinian basis for evolution. We argue that, for the Lamarckian model of evolution to be ruled out by the experiment, the experiment must favor pure Darwinian evolution over both the Lamarckian model and a model that allows both Darwinian and Lamarckian mechanisms. Analysis of the combined model was not performed in the original 1943 paper. The Luria-Delbruck paper also did not consider the possibility of neither model fitting the experiment. Using Bayesian model selection, we find that the Luria-Delbruck experiment, indeed, favors the Darwinian evolution over purely Lamarckian. However, our analysis does not rule out the combined model, and hence cannot rule out Lamarckian contributions to the evolutionary dynamics.