From short-range repulsion to Hele-Shaw problem in a model of tumor growth

TL;DR

This paper derives a modified macroscopic model for tumor growth that captures long-term behavior and Hele-Shaw limits, addressing computational challenges of microscopic simulations.

Contribution

It introduces a density-threshold modification to the macroscopic equation, improving qualitative accuracy and linking microscopic and macroscopic tumor growth models.

Findings

Modified macroscopic equation matches micro-dynamics numerically.

Asymptotic limit leads to Hele-Shaw type problem.

Model reduces computational time for large cell populations.

Abstract

We investigate the large time behavior of an agent based model describing tumor growth. The microscopic model combines short-range repulsion and cell division. As the number of cells increases exponentially in time, the microscopic model is challenging in terms of computational time. To overcome this problem, we aim at deriving the associated macroscopic dynamics leading here to a porous media type equation. As we are interested in the long time behavior of the dynamics, the macroscopic equation obtained through usual derivation method fails at providing the correct qualitative behavior (e.g. stationary states differ from the microscopic dynamics). We propose a modified version of the macroscopic equation introducing a density threshold for the repulsion. We numerically validate the new formulation by comparing the solutions of the micro- and macro- dynamics. Moreover, we study the asymptotic behavior of the dynamics as the repulsion between cells becomes singular (leading to non-overlapping constraints in the microscopic model). We manage to show formally that such an asymptotic limit leads to a Hele-Shaw type problem for the macroscopic dynamics. The macroscopic model derived in this paper therefore enables to overcome the problem of large computational time raised by the microscopic model and stays closely linked to the microscopic dynamics.