A stochastic model for directional changes of swimming bacteria

TL;DR

This paper introduces a stochastic model based on a Langevin equation to describe the directional changes of swimming bacteria, capturing both run and tumble behaviors through a unified framework and fitting experimental data.

Contribution

The work develops a novel stochastic model that unifies the description of bacterial run and tumble motions using a single control parameter and analytical solutions.

Findings

The model accurately fits experimental PDFs of turn angles.

Tumble motion is driven by rotational boosts and noise.

Run motion is characterized as an Ornstein-Uhlenbeck process.

Abstract

In this work we introduce a stochastic model to describe directional changes in the movement of swimming bacteria. We use the probability density function (PDF) of turn angles, measured on tumbling wild-type {\it E. coli}, to build a Langevin equation for the deflection of the bacterial body swimming in isotropic media. We have solved this equation analytically by means of the Green function method and shown that three parameters are sufficient to describe the movement: the characteristic time, the steady-state solution and the control parameter. We conclude that the tumble motion, which is manifested as abrupt turns, is primarily caused by the rotational boost generated by the flagellar motor and complementarily by the rotational diffusion introduced by noise. We show that in the tumble motion the deflection is a non-stationary stochastic process during times at which the tumbling occurs. By tuning the control parameter our model is able to explain small turns of the bacteria around their centres of mass along the run. We show that the deflection during the run is an OrnsteinUhlenbeck process, which for typical run times is stationary. We conclude that, along the run, the rotational boosts do not exist and that only the rotational diffusion remains. Thus we have a single model to explain the turns of through a critical value that can explain the transition between the two turn behaviours. This model is the bacterium during the run or tumble movements, through a control parameter that can be tuned also able to explain in a very satisfactory way all available statistical experimental data, such as PDFs and average values of turning angles times, of both run and tumble motions.