How structure sculpts function: unveiling the contribution of anatomical connectivity to the brain's spontaneous correlation structure

TL;DR

This paper introduces a novel analytical measure, $\\mathcal{T}$, that links anatomical brain connectivity to spontaneous functional correlations, revealing how network topology influences brain activity patterns.

Contribution

It develops a new measure of topological similarity that predicts how anatomical connectivity shapes the brain's spontaneous correlation structure.

Findings

The measure $\\mathcal{T}$ effectively predicts correlation patterns from network topology.

Topology explains a large part of the observed resting-state functional connectivity.

The approach generalizes existing indices like the matching index to complex brain networks.

Abstract

Intrinsic brain activity is characterized by highly structured co-activations between different regions, whose origin is still under debate. In this paper, we address the question whether it is possible to unveil how the underlying anatomical connectivity shape the brain's spontaneous correlation structure. We start from the assumption that in order for two nodes to exhibit large covariation, they must be exposed to similar input patterns from the entire network. We then acknowledge that information rarely spreads only along an unique route, but rather travels along all possible paths. In real networks the strength of local perturbations tends to decay as they propagate away from the sources, leading to a progressive attenuation of the original information content and, thus, of their influence. We use these notions to derive a novel analytical measure, $\mathcal{T}$ , which quantifies the similarity of the whole-network input patterns arriving at any two nodes only due to the underlying topology, in what is a generalization of the matching index. We show that this measure of topological similarity can indeed be used to predict the contribution of network topology to the expected correlation structure, thus unveiling the mechanism behind the tight but elusive relationship between structure and function in complex networks. Finally, we use this measure to investigate brain connectivity, showing that information about the topology defined by the complex fabric of brain axonal pathways specifies to a large extent the time-average functional connectivity observed at rest.