Control Strategy for Anaesthetic Drug Dosage with Interaction Among Human Physiological Organs Using Optimal Fractional Order PID Controller

TL;DR

This paper presents an optimal fractional order PID control strategy for anaesthetic drug infusion that accounts for interactions among human organs, aiming to minimize drug use while maintaining robustness against patient variability.

Contribution

It introduces a fractional order PID controller optimized with PSO for physiological interaction models, improving drug efficiency and robustness in anaesthetic delivery.

Findings

Reduced drug infusion amounts achieved.

High robustness to parametric uncertainties.

Effective control of brain response to anaesthesia.

Abstract

In this paper, an efficient control strategy for physiological interaction based anaesthetic drug infusion model is explored using the fractional order (FO) proportional integral derivative (PID) controllers. The dynamic model is composed of several human organs by considering the brain response to the anaesthetic drug as output and the drug infusion rate as the control input. Particle Swarm Optimisation (PSO) is employed to obtain the optimal set of parameters for PID/FOPID controller structures. With the proposed FOPID control scheme much less amount of drug-infusion system can be designed to attain a specific anaesthetic target and also shows high robustness for +/-50% parametric uncertainty in the patient's brain model.