Diffusion and Perfusion Magnetic Resonance Imaging:Fundamentals and Advances

TL;DR

This paper reviews the fundamentals and recent advances in diffusion and perfusion MRI, highlighting their applications in diagnosing and treating neurological conditions like Alzheimer's, tumors, and ischemic injuries.

Contribution

It provides a comprehensive overview of the physics, techniques, and clinical applications of diffusion and perfusion MRI in neurovascular diseases.

Findings

Diffusion MRI reveals tissue microstructure changes.

Perfusion MRI serves as an early biomarker for brain diseases.

Both modalities are highly sensitive to cellular microenvironment alterations.

Abstract

Over the past few decades, magnetic resonance imaging has been utilized as a powerful imaging modality to evaluate the structure and function of various organs in the human body,such as the brain. Additionally, diffusion and perfusion MR imaging have been increasingly used in neurovascular clinical applications. In diffusion-weighted magnetic resonance imaging, the mobility of water molecules is explored in order to obtain information about the microscopic behavior of the tissues. In contrast, perfusion weighted imaging uses tracers to exploit hemodynamic status, which enables researchers and clinicians to consider this imaging modality as an early biomarker of certain brain diseases. In this review, the fundamentals of physics for diffusion and perfusion MR imaging both of which are highly sensitive to microenvironmental alterations at the cellular level as well as their application in the treatment of aging, Alzheimer's disease, brain tumors and cerebral ischemic injury were discussed.